This book focuses on hematopoietic and lymphoid neoplasms that initially present as peripheral blood abnormalities, with either cytopenias or elevated peripheral blood counts, as well as non-neoplastic conditions that may raise concern for a hematologic malignancy. The scope of the book includes myelodysplastic syndromes (MDS), myeloproliferative neoplasms (MPN), mixed myelodysplastic/myeloproliferative neoplasms (MDS/MPN), as well as lymphomas and lymphoid leukemias that typically present initially with peripheral blood abnormalities. Within each category, a comprehensive list of differential diagnoses is discussed. For each disease entity, the reader is updated with new molecular genetic data, biomarkers, and recent applications of immunophenotyping, and how to incorporate the new information in disease diagnosis and classifications is illustrated, including the use of diagnostic algorithms where appropriate. The book employs the revised WHO Classification of Hematopoietic Neoplasmsfor all disease entities. Diagnosis of Blood and Bone Marrow Disorders will serve as a very useful resource for pathologists, pathologists in training, hematologists and medical technologists who are involved in the clinical work-up of patients with bone marrow and blood neoplasms. It will provide a practical and concise yet comprehensive review.

Secondary Causes of Cytopenias

Bone Marrow Failure Syndromes
Myelodysplastic Syndromes and Acute Leukemias
Secondary Causes of Leukocytosis
Myeloid Neoplasms Associated with Leukocytosis
Secondary Causes of Thrombocytosis
Myeloid Neoplasms Associated with Thrombocytosis
Myeloid Neoplasms Associated with Leukocytosis and/or Thromboctysis and Cytopenia(s)
Secondary Causes of Erythrocytosis
Polycythemia Vera
Secondary Causes of Eosinophilia
Myeloid Neoplasms Associated with Eosinophilia
Secondary Causes of Monocytosis
CMML
JMML
Other Myeloid Neoplasms Associated with Monocytosis Including Acute Monocytic Leukemias
Reactive Lymphocytosis
T/NK-cell Neoplasms
B-cell Neoplasms
Plasma Cell Neoplasms.