Drug Delivery Challenges and Novel Therapeutic Approaches for Retinal Diseases

Drug Delivery Challenges and Novel Therapeutic Approaches for Retinal Diseases

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This book reviews the current state of ocular drug therapy and future therapeutic opportunities for a wide variety of conditions, including Age-related Macular Degeneration, Diabetic Retinopathy and Macular Edema, Glaucoma, and Inherited Retinal Diseases.

Retinal diseases are major contributors to moderate or severe vision impairment in adults aged 50 years and older. The respective patient populations for many of these indications is expected to significantly increase as the world population continues to grow older. An improved understanding of the etiological underpinnings of ocular degenerative diseases over the past decade has significantly bolstered ophthalmic drug discovery.

In this volume, contributions from leading experts explore the unique challenges faced for ocular drug discovery and delivery providing the reader with detailed information on ocular pharmacokinetics, in vitro, ex vivo and in vivo models for retinal disease pathology and emerginggene therapy treatments. The book is intended for all researchers and clinicians who wish to increase their knowledge on the latest findings in ocular drug therapy.




An Overview of Retinal Diseases and Current Ocular Drug Discovery
Ocular Pharmacokinetics and Drug Delivery Challenges
Models of Pathologies Associated with Age-related Macular Degeneration and Their Utilities in Drug Discovery
Recent Developments in Agents for the Treatment of Age-Related Macular Degeneration and Stargardt Disease
Targets and Strategies toward the Development of Therapeutics for Diabetic Retinopathy and Diabetic Macular Edema
Recent Developments for the Treatment of Glaucoma
Emerging Gene Therapy Treatments for Retinal Degenerative Diseases.  
ISBN 978-3-030-56621-0
Media type Book
Edition number 1st ed. 2020
Copyright year 2021
Publisher Springer, Berlin
Length IX, 272 pages
Language English