Chaouki, Jamal , Zarghami, Reza , Sotudeh-Gharebagh, Rahmat

Iterative Scale-Up in the Chemical Process Industry

e-Pilot, Mixing, Process Analytics, Digital Scale-Up, Data-Driven Scale-Up

Chaouki, Jamal , Zarghami, Reza , Sotudeh-Gharebagh, Rahmat

Iterative Scale-Up in the Chemical Process Industry

e-Pilot, Mixing, Process Analytics, Digital Scale-Up, Data-Driven Scale-Up

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Description Authors

Common scale-up methods are conventional where the blind piloting is essential. This imposes huge investment and leads to failures mostly in solid processing. However, the limitations of resources, current shortcomings, short time-to-market demand are forcing companies to minimize piloting. With these situations in mind, current digitalization outlook and computational facilities, we proposed and developed a novel iterative scale up method with case studies which highly expedites the process innovation through the following key sequences:

To move from literature and laboratory studies to commercial design.

To reduce risks by reevaluating literature, lab studies, e-pilot or adequate pilots if needed.

To iterate between commercial to lab, e-pilot and pilot with CAPEX, OPEX and LCA.

New to the second edition: expands on E-pilot, presents Scale-up of Agitated Vessels and includes new case studies.

ISBN	9783111592619
Media type	Book
Edition number	2. Aufl.
Copyright year	2026
Publisher	De Gruyter
Illustrations	20 b/w and 100 col. ill., 45 b/w and 1 col. tbl.
Language	English