Measles, also called the greatest killer of children in history, still annually affects about 50 million individuals and causes close to a million deaths primarily in developing countries. Before the advent of measles vaccine some 30 years ago, these figures were roughly three times higher. Attenuated measles virus (MV) strains, all quite closely related to the original Edmonston isolate, have a very good record as a safe and highly efficacious vaccine and have brought down the measles toll in industrialized countries to almost negligible levels. However, recent outbreaks in the USA and Europe have again brought the measles problem to public attention. Sadly enough, these outbreaks were more instrumental in inducing activities to drastically reduce and hopefully finally eradicate measles than were the ten thousand times higher number of victims in developing countries. To reach this goal, as detailed in this volume, apparently it is not enough to of the existing vaccine as was the rigorously enforce use case with smallpox eradication: the intricacies of measles disease phenomena, in particular the generalized immune suppression which favors secondary infections, require more basic knowledge of the virus-host interactions and probably the development of new vaccines for special applications such as first immunizations of very young infants in developing countries.

List of Contents

Clinical Spectrum of Measles
The Epidemiology of Measles: Thirty Years of Vaccination
Structure, Transcription, and Replication of Measles Virus
Functional Aspects of Envelope-Associated Measles Virus Proteins
Measles Virus Strain Variations
Measles Virus-Mononuclear Cell Interactions
Measles Virus Gene Expression in Neural Cells
Immune Responses During Measles Virus Infection
Monkeys in Measles Research
Measles Virus Infections in Rodents
The Paradigms of Measles Vaccinology
Appendix: Measles Virus Antigenome and Protein Consensus Sequences.