The 1st International Workshop in the Molecular and Cell Biology of Autoan tibodies and Autoimmunity is convened at a time when recombinant DNA tech niques have yielded the first set of data providing initial glimpses of epitopes recognized by autoantibodies. It's aim is to bring together cell and molecular biologists with clinical scien tists to discuss the broad spectrum of questions concerning the relationship be tween clinical symptoms and the specificity of autoantibodies. The response to the call for abstracts was overwhelming: Nearly one hundred abstracts were received from many laboratories throughout the world. The topics covered by them are representative of the current research efforts going on to study cause and effect of autoimmune diseases. One of the aims of this workshop is to bring the rapid advances in the elucidation of the molecular structure of auto antigens to the attention of immunologists, cell biologists and clinical scien tists and also to make molecular biologists bei6ple aware of the difficulties lying ahead in trying to understand the cellular and molecular basis of rheumatic dis eases. The organisers wish to thank NIH, BMFT and the Japanese Educational Foundation for financial support, the Heidelberg Academy for the Humanities and Sciences for hosting the workshop, Springer Verlag for their generous cooperation in including late abstracts in this volume, and, last not least, Ms. Simone KRAMBS for untiring secretarial help.

Clinical and Etiopathogenetic Significances of Autoantibodies to the Cellular Antigens in Systemic Connective Tissue Diseases

Cloning of a cDNA-Fragment Coding for an Epitope Recognized by Anti-PM/Scl-Autoantibodies
Fibrillarin from Xenopus laevis: cDNA Cloning and Expression During Development
Nuclear Receptors as Transcriptional Enhancers
Multiple Components of SS-A/Ro Autoantigen: cDNA Cloning of the 52 kDa Protein
Autoantibodies to Nuclear Envelope Proteins: Characterization and Clinical Significance
Cloned Human snRNP Proteins B and B? Differ Only in Their Carboxy-Terminal Part
Antibodies to Ribonucleoprotein (RNP) from Autoimmune Sera Detected by Immunoblot on Tissue Extracts
Analysis of the 60 kD Ro Protein - hY RNA Complex: An RNA Recognition Motif Within Ro Protein is Required for Binding to hY 1 RNA
Monoclonal Autoantibodies Against Nuclear Proteins
Alterations of the Macrophage System in Systemic Lupus Erythematosus (SLE) Developing NZB/W Mice
Cytoskeletal Proteins: Major Antigens in Autoimmune Diseases
Leucine Periodicity of U2 snRNP Autoantigen A? Implicated in U2 snRNP Protein: Protein Interactions
Epitope Mapping of the Recombinant Human U1 snRNP 68 k Protein
Molecular Characterization of the PM/SCL Antigen
Chronic Graft-versus-Host Disease. A Model for the Study of the Autoimmune Phenomenon
Immunogenetic Studies in Patients with Scleroderma-Associated Autoantibodies
The TH Ribonucleoprotein Particle: Identity with RNase MRP and Association with RNase P
Immunoregulatory Effects of Borrelia Burgdorferi Antigens in Patients with Chronic Lyme Disease
Molecular Mimicry: A Common Epitope of the (U 1) snRNP Associated p68 Autoantigen and a Protein of a Human Pathogenic Virus
Human Autoantibodies to SynaptonemalComplex
Immunolocalization and Number of Transcriptionally Active rRNA Genes in Vertebrate Cells
Mapping of Autoimmune Reactive Sites on snRNP Proteins
Clinical Significances of Rare Autoantibodies to Small Nuclear and Cytoplasmic Ribonucleoproteins
Molecular Cloning and Expression of cDNAs Encoding snRNP Polypeptide Autoantigens
U 1-68 Kd Protein-Positive Mixed Connective Tissue Disease is Associated with HLA-DR4 and Appears Genetically Distinct from Systemic Lupus Erythematosus
A Novel Trait of Naturally-Occurring Anti-DNA Antibodies: Dissociation from Immune Complexes in Neutral 0.3-0.5 M NaC1
Immunoblotting Analysis in Antigenic Components of Circulating Immune Complexes of Rheumatoid Arthritis and Systemic: Lupus Erythematosus Patients
The Human La Autoantigen Contains an RNA Binding Domain and an ATP Binding Domain
Autoantibodies to "HSP 70 Class" Proteins in Sera of Systemic Lupus Erythematosus (SLE) Patients and Healthy Subjects. A Spontaneous Expression of HSP 70 Autoantibodies
Cross-Reactive Rheumatoid Factor in Rheumatoid Arthritis with Extra-Articular Disease
Profiles of Anti-Nuclear Antibodies in Scleroderma Spectrum Disorders
Desmin Antibodies in Acute Myopericarditis
Ankylosing Spondylitis (AS) and Rheumatoid Arthritis (RA): Improved Diagnosis and Attempts Towards the Molecular Analysis of Etiology and Pathogenesis of These Systemic Rheumatic Diseases
Characterization of the snRNP Protein N: Description of a Potential Sm Epitope
Antigenic Structure of U snRNPs and Experimental Induction of Anti-U snRNP Autoantibodies in Mice
The U 1 RNA Binding Site of the U 1 snRNP-Associated A Protein Overlaps an Anti-U1 RNA Antibody Binding Site
Anti-Ribosomal P Protein Antigens and Antibodies
Molecular Identification of theM2 Antigens of Primary Biliary Cirrhosis
Molecular Biological Identification of Autoantigens in Autoimmune Hepatitis - Relevance for Pathogenesis, Diagnosis, and Treatment
Aminoacyl-tRNA Synthetases: an Overview
A New Autoantibody Specific for the Limited Systemic Sclerosis (lSSc) Found Through Molecular Biology
Determination of an Epitope of the Diffuse Scleroderma Marker Antigen Topoisomerase I. Sequence Similarity with Retroviral p 30gag Protein Suggests a Possible Cause for Autoimmunity in Scleroderma
The Spectrum of Antinuclear Antibodies (ANA) and Clinical Findings in Children with Anti-U 1-RNP Antibodies
Molecular Cloning of the Human Autoantigen KU (p 70/p 80), a DNA-Terminal-Binding Protein Complex
Autoantibodies to a Histone Cross-Reactive DNA-Binding Protein of Mr 110000 in Systemic Lupus Erythematosus and Other Diseases and in Autoimmune Mice
cDNA Cloning and Expression of U1snRNP C Protein
Further Characterization of the Anti-Wa Antibody to a tRNA-Related Protein in Progressive Systemic Sclerosis
Characteristics and Interrelation of Autoantibodies in Scleroderma Sera
Characterization of an Autoantigen in Graves' Hyperthyroidism
Clinical Significance of Anti-Ubiquitin Antibodies in Systemic Lupus Erythematosus
The Natural History of PCNA/Cyclin
Identification of Several Independent Autoreactive Epitopes of the Human 68 kDa (U 1) snRNP-Autoantigen
Current Ideas on Tolerance Mechanisms and Autoimmunity
Molecular Cloning of a cDNA for the B-Polypeptide of the U snRNPs
The Induction of Anti-DNA Antibodies in Normal Mice by Immunization with Bacterial DNA
The Binding of Anti-La Antibodies to Fusion Proteins Containing Various La Epitopes
Isolation and Sequencing of Human Lamin ? cDNA: Mammalian Lamins A, B and C ContainLeucine Heptad Repeats
Detection of Autoantibodies Using Recombinant Antigens
A Common RNA Recognition Motif Identified Within a Defined U 1 RNA-Binding Domain of the 70K U1 snRNP Autoantigen
Characterization of Nucleolar 7-2 RNP Recognized by Sera from Patients with Autoimmune Diseases
Structure and Antigenicity of the p70 (Ku) Autoantigen
Synthetic Peptides as Probes for Autoantibodies
cDNA Sequencing and Expression of B/B?-Proteins of RNP Autoantigens in E. coli
Compartmentalization of Nuclear Antigens Detected by Autoantibodies
Anti-A. R.: A New Autoantibody/ies in Autoimmune Chronic Active Hepatitis (CAH) that Precipitates a 4.5 S RNA
Immunological Crossreactivity Between RNA Polymerase I and the Glycine Rich Repeats of Epstein-Barr Virus Nuclear Antigen
Drug Induced Anti-Histone Antibodies Reflect Nucleosomal Substructures
Epitope Mapping of the Ro-RNP Autoantigen Using Recombinant Polypeptides
Idiotype Network and Anti-DNA Antibody Production
In Vitro Binding of A and B? snRNP Proteins to U1 and U2 snRNAs
Expression of the 70 kD RNP Autoantigen in E. coli and Its Use in ELISA-Screening of Patients Sera
The Autoantibody Expression in Cultured Cell Lines of Human Keratinocytes Transformed by Virus and by Ultraviolet Light in SLE and Other Autoimmune Diseases
The B Cell Activation in Autoimmunity
Rheumatoid Factor Idiotypes in Lymphoproliferative Disorders in Patients with Sjörgren's Syndrome
Snurps and Scyrps - Insights into the Biology of RNA Processing
Genetic Restriction of Autoantibody Production in Patients with Systemic Lupus Erythematosus
Localization of an Immunopathologically Important Epitope in the Bovine Retinal S-Antigen by the Pepscan Method
Anti-Peptide Antibodies to Three CDR Sequences of HumanMonoclonal Anti-DNA Autoantibodies
Immunological Characterization of IgM Class Autoantibodies Against Sm-Antigenic B?/B and D Polypeptides of U Small Nuclear Ribonucleoproteins (snRNPs)
Enzyme-Linked Immunosorbent Assay Using Isolated (U) Small Nuclear Ribonucleoprotein Polypeptides as Antigens
Analysis of U1 Ribonucleoprotein (RNP) 68K Polypeptide (p 68K) Epitopes by Enzyme-Linked Immunosorbent Assay (ELISA) with Fusion Proteins (FPs)
Contributions of Molecular and Cell Biology to Understanding of the B-Cell Response in Systemic Autoimmunity
Immunospecificity and Clinical Association of Autoantibodies in Sera Precipitating U1 and U2 Small Nuclear RNAs
Anti-JO-1 Antibodies are Directed at an Evolutionarily-Conserved, Conformational Site on Human Histidyl-tRNA Synthetase
Molecular Considerations of Primary Biliary Cirrhosis: Definition of Dihydrolipoamide Acetyltransferase and Identification of Immunoreactive Sites
Association of Seropositive Rheumatoid Arthritis (RA) with the Third Hypervariable Region (HVR3) of the HLA-DR ?1-Chain: Functional Implications for Antigen-Specific and Allogeneic T Cell Recognition
The snRNP E Protein: Structure and Expression of a Human Autoimmune Antigen
Autoantibodies to Nonhistone Chromosomal Proteins HMG-1 and HMG-2 in Subsets of Juvenile Chronic Arthritis (JCA)
A Human T Cell Clone Recognizing Small Nuclear Ribonucleoproteins (UsnRNP)
Epitope Progression in Autoantibody Production Suggested by Epitope Mappings of SS-B/La and U2snRNP B? Protein
Association of Autoantigenic Epitope and Catalytic Site on Poly (ADP-Ribose) Polymerase
Rheumatoid Arthritis is Associated with the Presence of Anti-Nuclear Antibodies to a 33kD Protein (RA 33) and Related Antigens
Molecular Cloning and Identification ofRetroviral Nucleic Acids Associated with Systemic Lupus Erythematosus
Molecular Features of an RNA Recognition Motif Family of Proteins
Detection of HIV-Homologous DNA and RNA in Systemic Lupus Erythematosus
Heterogeneity of the Ro(SSA) Antigen and the Autoanti-Ro(SSA) Response: Evidence for 4 Antigenically Distinct Forms
Molecular Cloning of Ki Antigen C DNA and Enzyme-Linked-Immunosorbent-Assay for Anti-Ki Using Recombinant Ki
Antibodies to Nuclear Lamin C in Chronic Hepatitis Delta Virus Infection.