The essays in this book discuss the role that chemicalagents in the environment play in the development of cancer.Thus, it gives information toimprove our understanding ofcarcinogenesis and how to prevent it. The essays wereoriginally presented at an international symposium.

Honorary lecture Risk Assessment and Management of Toxic Chemicals: The Needs and Guidelines for Developing Countries

Molecular Basis of Risk Assessment
Individual Genetic Constellations as Risk Factors in Chemical Carcinogenesis
Mechanistic Analysis as a Tool for Carcinogen Risk Assessment
Molecular Genetic Alterations such as Oncogene Activation as a Tool for the Evaluation of Risks in Chemical Carcinogenesis
Initiation and Promotion - Useful Concepts for Risk Assessment?
Human Exposure to Chemical Carcinogens
Risk Assessment of Naturally Occurring Carcinogens
Carcinogenic Drugs and their Relevance in Risk Assessment
A Weight-of-Evidence Approach to Quantitative Cancer Risk Assessment: Information Analysis
Biologically Based Pharmacokinetics and Cancer Risk Assessment
Evaluation of Epidemiologic Study Designs for the Assessment of Risk in Chemical Carcinogenesis
The Role of 'Negative' and 'Nonpositive' Studies in Occupational Epidemiology
Weak Associations in Occupational Epidemiology and the Criteria for Deducing Causality
Aspects of Clinical Oncology in the Assessment in Chemical Carcinogenesis
Regulations in Risk Assessment
Provisions on Carcinogenic Substances in the Federal Republic of Germany and the European Community
Regulations on Chemical Carcinogenesis of the Environmental Protection Agency (EPA)
Regulation of Chemical Carcinogenesis in Japan
Acknowledgements
Invited Speakers and Chairmen.