Signalling from Internalised Growth Factor Receptors
Signalling from Internalised Growth Factor Receptors
This book reviews knowledge on the interconnection of signal transduction and endocytosis/intracellular trafficking. The chapters cover knowledge obtained by using different model systems. The first chapter deals with Receptor Tyrosin Kinases (RTKs) with emphasis on the Epidermal Growth Factor Receptor (EGF receptor) and the Platelet Derived Growth Factor Receptor (PDGF receptor). The second chapter deals with the RTK c-Met and with how this RTK becomes carcinogenic. The third chapter reviews recent understanding on the mechanisms of action of the numerous fibroblast growth factors and their receptors. In the fourth chapter we learn about the trafficking of and signalling from the Growth Hormone Receptor and how this receptor is controlled by ubiquitination. The fifth chapter is devoted to the Interleukin II receptor, essential for activation of T cells. Links between ubiquitination, signalling, endocytosis, and sorting are reviewed. The last chapter discusses current views on how monoubiquitination controls both signalling and trafficking and thereby the final outcome of receptor activation.
List of Contents
Receptor Tyrosine Kinase Signaling and Trafficking-Paradigms RevisitedMet Receptor Dynamics and Signalling
Signaling, Internalization, and Intracellular Activity of Fibroblast Growth Factor
Ubiquitin System-Dependent Regulation of Growth Hormone Receptor Signal Transduction
Clathrin-Independent Endocytosis and Signalling of Interleukin 2 Receptors IL-2R Endocytosis and Signalling
Signaling Through Monoubiquitination.
Madshus, Inger Helene
| ISBN | 978-3-642-05912-4 |
|---|---|
| Media type | Book |
| Copyright year | 2011 |
| Publisher | Springer, Berlin |
| Length | IX, 190 pages |
| Language | English |
