Chemical Genomics
Small Molecule Probes to Study Cellular Function
Chemical genomics is a highly interdisciplinary and very exciting field of research both in academics and in the life sciences industry. The Ernst Schering Research Foundation Workshop 58 was organized to bring together scientific leaders in the field to discuss the implications of chemical genomics for drug discovery. Various aspects of the interface between chemistry and biology are covered in this volume, such as chemogenomics efforts in the pharmaceutical industry, diversity-oriented synthesis, chemogenomic approaches to the study of cell function, screening technologies, and natural products as tools in chemical biology.
1;Preface;5 2;Contents;8 3;List of Editors and Contributors;10 4;1 Chemogenomics in Drug Discovery;14 5;2 Chemogenomics Strategies for G- Protein Coupled Receptor Hit Finding;33 6;3 Chemogenomics Approaches to G- Protein Coupled Receptor Lead Finding;42 7;4 Diversity Oriented Synthesis: A Challenge for Synthetic Chemists;58 8;5 Probing Protein Function with Small Molecules;72 9;6 Tamoxifen- Based Probes for the Study of Estrogen Receptor- Mediated Transcription;86 10;7 Protein Structure Similarity Clustering and Natural Product Structure as Guiding Principles for Chemical Genomics;99 11;8 Tackling the Chemogenomic Space by Novel Screening Technologies;120
| ISBN | 9783540376354 |
|---|---|
| Article number | 9783540376354 |
| Media type | eBook - PDF |
| Edition number | 2. Aufl. |
| Copyright year | 2007 |
| Publisher | Springer-Verlag |
| Length | 179 pages |
| Language | English |
| Copy protection | Digital watermarking |
