The modern era of radionuclide imaging and therapy is well into its seventh decade. During this era, many national and international textbooks have been published in an attempt to educate not only the practitioners of our medical discipline, but also referring physicians and medical students. Some of the more recent large multic- tural texts, such as those by Ell and Ghambir, Sandler et al. and Henkin et al. , provide us with very comprehensive reference sources while some of the smaller texts totally writtenbytwo or threeindividuals,e. g. Mettler &Guiberteauand Ziessman,O'M- ley & Thrall, have achieved popularity with radiology residents and other physicians in training. The concept of Clinical Nuclear Medicine arose 3 years ago from a conversation between the editors, who have been close friends for many years. We have always felt that our relationship epitomizes one of the major strengths of nuclear medicine, which is the very close ties and spirit of educational cooperation that exist between international colleagues. We all share the same aim of doing whatever we can to op- mize patient care whether it be by introducing new pharmaceuticals and inst- ments or by developing new techniques or approaches to performing our broad spectrum of clinical procedures. Nuclear medicine physicians have almost uniformly been willing to share their expertise at national and international meetings. The - ternational nuclear medicine community, unlike many other larger specialty areas, has remained relatively small. It was within this spirit that Clinical Nuclear Medicine was born.

1;Preface;5 2;Contents;6 3;List of Contributors;22 4;Physics, Instrumentation, and Radiation Protection;27 5;Radiochemistry and Radiopharmacy;60 6;Brain ;103 7;Heart ;121 8;Lung;144 9;Liver, Spleen and Biliary Tree ;173 10;Kidney;198 11;Lower Genitourinary Tract ;225 12;Gastrointestinal System ;239 13;Musculoskeletal System ;267 14;Malignant Melanoma and Soft Tissue Sarcomas ;289 15;Sentinel Node Biopsy and Occult Lesion Localization in Early Breast Cancer;297 16;FDG-PET and PET-CT Imaging of Head and Neck Cancers;305 17;The Endocrine System;313 18;Nuclear Hematology ;333 19;Hodgkin's Disease and Lymphomas;348 20;Scintigraphic Detection of Infection and Inflammation;373 21;The Relevance of PET in Diagnostic Oncology;386 22;Miscellaneous;418 23;Practical Considerations in the Radionuclide Imaging of Children;421 24;Radioiodine Therapy for Benign Thyroid Disease;435 25;Radioiodine Therapy: Malignant Thyroid Disease;444 26;Radionuclide Therapy of Bone Metastases ;459 27;Peptide Receptor Radionuclide Therapy;469 28;Neuroendocrine Tumors (MIBG);482 29;Radioimmunotherapy ;493 30;Intra-arterial Therapy of Liver Tumours;517 31;Radioisotope Therapy of Malignant Pleural and Peritoneal Effusions;535 32;Radiosynoviorthesis (Radiation Synovectomy);538 33;Miscellaneous ;545 34;Subject Index;562