In December 2019, the world witnessed the occurrence of a new coronavirus to humanity. The disease spread quickly and became known as a pandemic globally, affecting both society and the health care system, both the elderly and young groups of people, and both the men's and women's groups. It was a universal challenge that immediately caused a surge in scientific research. Be a part of a world rising in fighting against the pandemic, the Coronavirus Disease - COVID-19 was depicted in the early days of the pandemic, but updated by more than 200 scientists and clinicians to include many facets of this new infectious pandemic, including i, characteristics, ecology, and evolution of coronaviruses; ii, epidemiology, genetics, and pathogenesis (immune responses and oxidative stress) of the disease; iii, diagnosis, prognosis, and clinical manifestations of the disease in pediatrics, geriatrics, pregnant women, and neonates; iv, challenges of co-occurring the disease with tropical infections, cardiovascular diseases, hypertension, and cancer and to the settings of dentistry, hematology, ophthalmology, and pharmacy; v, transmission, prevention, and potential treatments, ranging from supportive ventilator support and nutrition therapy to potential virus- and host-based therapies, immune-based therapies, photobiomodulation, antiviral photodynamic therapy, and vaccines; vi, the resulting consequences on social lives, mental health, education, tourism industry and economy; and  vii, multimodal approaches to solve the problem by bioinformatic methods, innovation and ingenuity, globalization, social and scientific networking, interdisciplinary approaches, and art integration. We are approaching December 2020 and the still presence of COVID-19, asking us to call it COVID (without 19).

Chapter 1. Introduction on Coronavirus Disease (COVID-19) Pandemic: The Global Challenge (Nima Rezaei, Saboura Ashkevarian, Mahsa Keshavarz Fathi, Sara Hanaei, Zahra Kolahchi, Seyedeh-Sanam Ladi Seyedian, Elham Rayzan, Mojdeh Sarzaeim, Aida Vahed, Kawthar Mohamed, Sarah Momtazmanesh, Negar Moradian, Zahra Rahimi Pirkoohi, Noosha Sameeifar, Mahsa Yousefpour, Sepideh Sargoli, Saina Adiban, Aida Vahed, Niloufar Yazdanpanah, Heliya Ziaei, Amene Saghazadeh)

Chapter 2. Coronaviruses: What Should We Know About the Characteristics of Viruses? (Wei Ji)
Chapter 3. Ecology and Evolution of Betacoronaviruses (Eduardo Rodríguez-Román, Adrian J. Gibbs)
Chapter 4. The Epidemiologic Aspects of COVID-19 Outbreak: Spreading Beyond Expectations (Sara Hanaei, Farnam Mohebi, Maziar Moradi-Lakeh, Parnian Jabbari, Surinder Kumar Mehta, Liudmyla S. Kryvenko, Livio Luongo, Lodc Dupré, Nima Rezaei)
Chapter 5. The Incubation Period of COVID-19: Current Understanding and Modeling Technique (Char Leung).-Chapter 6. Coronavirus: Pure Infectious Disease or Genetic Predisposition (Farzaneh Darbeheshti, Hassan Abolhassani, Mohammad Bashashati, Saeid Ghavami, Sepideh Shahkarami, Samaneh Zoghi, Sudhir Gupta, Jordan S. Orange, Hans D. Ochs, Nima Rezaei)
Chapter 7. Genetic Polymorphisms in the Host and COVID-19 Infection (Joris R. Delanghe, Marc L. De Buyzere, Marijn M. Speeckaert)
Chapter 8. How COVID-19 Has Globalized: Unknown Origin, Rapid Transmission, and the Immune System Nourishment (Amene Saghazadeh, Nima Rezaei)
Chapter 9. Potential Anti-viral Immune Response Against COVID-19: Lessons Learned from SARS-CoV (Mahzad Akbarpour, Laleh Sharifi, Amir Reza Safdarian, Pooya Farhangnia, Mahdis Borjkhani, Nima Rezaei)
Chapter 10. COVID-19 and Cell Stress (Abdo A Elfiky, Ibrahim M Ibrahim, Fatma G Amin, Alaa M Ismail, Wael M Elshemey)
Chapter 11. Clinical Manifestations of COVID-19 (Mahsa Eskian, Nima Rezaei)
Chapter 12. Pediatrics and COVID-19 (Tuna Toptan, Sandra Ciesek, SebastianHoehl)
Chapter 13. Geriatrics and COVID-19 (Mona Mirbeyk, Amene Saghazadeh, Nima Rezaei)
Chapter 14. Coronavirus Diseases in Pregnant Women, the Placenta, Fetus, and Neonate (David A. Schwartz, Amareen Dhaliwal)
Chapter 15. COVID-19 in Patients with Hypertension (Thiago Quinaglia, Mahsima Shabani, Nima Rezaei)
Chapter 16. COVID-19 and Cardiovascular Diseases (Babak Geraiely, Niloufar Samiei, Parham Sadeghipour, Azita Haj Hossein Talasaz, Seyedeh Hamideh Mortazavi, Roya Sattarzadeh Badkoubeh)
Chapter 17. How Prevalent Is Cancer in Confirmed Cases with Coronaviruses and Severe Acute Respiratory Syndromes? (Maryam Fotouhi, Elham Samami, Sahar Mohseni, Amir Nasrollahizadeh, Mohammad Haddadi, Mona Mirbeyk, Amene Saghazadeh, Nima Rezaei)
Chapter 18. COVID-19 in Patients with Cancer (Ali Nowroozi, Sepideh Razi, Kamal Kant Sahu, Fabio Grizzi, Jann Arends, Mahsa Keshavarz-Fathi, Nima Rezaei)
Chapter 19. COVID-19 and Tropical Infection: Complexity and Concurrence (Pathum Sookaromdee, Viroj Wiwanitkit)
Chapter 20. Neurologic Manifestations of COVID-19 (Farnaz Delavari, Farnaz Najmi Varzaneh, Nima Rezaei)
Chapter 21. Autoimmune Processes Involved in Organ System Failure Following Infection with SARS-CoV-2 (Steven E. Kornguth, Robert J. Hawley)
Chapter 22. Clinical and Laboratory Predictors of Severity, Criticality, and Mortality in COVID-19: A Multisystem Disease (Bahareh Gholami, Samira Gholami, Amir Hossein Loghman, Behzad Khodaei, Simin Seyedpour, Nasrin Seyedpour, Amene Saghazadeh, Nima Rezaei)
Chapter 23. Diagnostic Tests for COVID-19 (Tung Phan, Kristin Nagaro)
Chapter 24. The Role of Medical Imaging in COVID-19 (Houman Sotoudeh, Masoumeh Gity)
Chapter 25. Therapeutic Development in COVID-19 (Chan Yang, Yuan Huang, Shuwen Liu)
Chapter 26. Immune-based Therapy for COVID-19 (Abdolreza Esmaeilzadeh, Davood Jafari, Safa Tahmasebi, Reza Elahi, Elnaz Khosh)
Chapter 27. Ventilatory Support in Patients with COVID-19 (Paolo Maria Leone, Matteo Siciliano