Intrinsic Immunity
Recent research has focused attention on the importance of intrinsic antiviral immunity, i.e. immunity mediated by factors that are constitutively expressed in many cells. In this volume, leading experts provide a comprehensive overview of this relatively new and rapidly evolving field. They cover intrinsic proteinaceous antiviral immune effectors, such as the APOBEC3 and TRIM protein families as well as Tetherin and SAMHD1, which were initially discovered by researchers studying HIV-1. Furthermore, the role of RNA interference in antiviral defense in plants and invertebrates, as well as the interplay between microRNAs and viruses in mammalian cells, are analysed. One chapter discusses how intrinsic immunity and viral countermeasures to intrinsic immune effectors drive both pathogen and host evolution, and finally the emerging evidence that DNA damage response proteins restrict infection by DNA viruses is highlighted.
The APOBEC3 Family of Retroelement Restriction Factors
Inhibition of Retroviral Replication by Members of the TRIM Protein Family
The Antiviral Activities of Tetherin
Restriction of Retroviral Infection of Macrophages
Rapid Adversarial Co-Evolution of Viruses and Cellular Restriction Factors
RNA Interference-Mediated Intrinsic Antiviral Immunity in Plants
RNA Interference-Mediated Intrinsic Antiviral Immunity in Invertebrates
Roles of MicroRNAs in the Life Cycles of Mammalian Viruses
Interplay Between DNA Tumor Viruses and the Host DNA Damage Response.
Cullen, Bryan R.
| ISBN | 978-3-642-37764-8 |
|---|---|
| Media type | Book |
| Copyright year | 2013 |
| Publisher | Springer, Berlin |
| Length | VII, 262 pages |
| Language | English |
