Perinatal Inflammation and Adult Psychopathology

From Preclinical Models to Humans

Perinatal Inflammation and Adult Psychopathology

From Preclinical Models to Humans

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Perinatal psychiatry is an emerging field that investigates the role of perinatal events - for example pregnancy complications and infections - in the development of neuropsychiatric conditions, such as schizophrenia and mood disorders. Among the implicated pathological mechanisms, perinatal-induced inflammation seems to play a major role and is being considered as a potential target for therapeutic intervention. 
 
Bringing together various approaches in the field (preclinical and clinical, epidemiological, immunological and genetic methods), the book discusses the available evidence, the putative mechanisms and the challenges ahead.




Chapter 1. Perinatal psychiatry: ready for prime time?- Chapter 2. Pregnancy, stress response and neuroinflammation: effects on offspring and risk for psychiatric disorders
Chapter 3. Epigenetic modifications of early life stress and adult life psychopathology
Chapter 4. Perinatal HPA programming and adult psychopatholgoy
Chapter 5. Intergeneration transmission of depression: focus on inflammation
Chapter 6. Neonatal bacterial meningitis: mechanisms and implications for adult life psychopathology
Chapter 7. Toxoplasmosis as risk factor for severe psychiatric disorders: clinical and pre-clinical evidence
Chapter 8. A critical appraisal on the epidemiological evidence linking perinatal inflammation and risk of psychosis
Chapter 9. Maternal Immune Activation as a Risk Factor for Schizophrenia: Evidence from Preclinical and Clinical Studies
Chapter 10. Influences of sex and age in MIA-induced behavioral and neurobiological alterations
Chapter 11. MIA and autism
Chapter12. Zika virus infection and neuropsychiatric complications
Chapter 13. Placenta immunology: impact on fetus development
Chapter 14. Placenta and cord blood as source of immune markers of offspring development and psychopathology
Chapter 15. Cytokine model of cognitive function.
ISBN 978-3-030-39334-2
Media type Book
Edition number 1st ed. 2020
Copyright year 2020
Publisher Springer, Berlin
Length XI, 268 pages
Language English