This book reviews recent work on molecular chaperones of the prefoldin family from their discovery in Archaea to the basic clarification of their structure. Even though, there is still a lot to investigate in order to understand the roles and functions of prefoldins, some preliminary work suggests their contribution in assembly and activation of a variety of macromolecular complexes. Hence, the reader is introduced to recent structural findings via cryo-electron microscopy and to the importance of this particular group of proteins in health and disease. This book also discusses the particular structure of the URI prefoldin-like complex. In addition, recent developments in the generation of URI mouse models speculate on the functions and emerging roles of the URI prefoldin-like complex in various cellular processes. This novel protein complex represents a unique cellular machinery, which molecular basis of its activity still remains to be determined.
This work is thus a guide to help researchers in the field to have a more comprehensive and critical view of the prefoldin world.
Preface.- Structure of the molecular chaperone prefoldin.- Structure and function of archaeal prefoldin.- Role and functions of prefoldins.- Nuclear functions of prefoldins.- The yeast prefoldin Bud27.- URI-like prefoldin complex.- HSP90 and its R2TP/Prefoldin-like cochaperone.- Role and functions of URI: mouse models for URI.- Nuclear function of URI-like prefoldin complex.- URI and androgen regulation. Index.
Djouder, Nabil
| ISBN | 978-3-030-00736-2 |
|---|---|
| Article number | 9783030007362 |
| Media type | Book |
| Edition number | 1st ed. 2019 |
| Copyright year | 2018 |
| Publisher | Springer, Berlin |
| Length | IX, 135 pages |
| Illustrations | IX, 135 p. 39 illus., 36 illus. in color. |
| Language | English |
