Progress in the Chemistry of Organic Natural Products 115
This book describes current understandings and recent progress into a varied group of natural products. In the first chapter the role that total synthesis may play in revising the structures proposed for decanolides, which are ten-membered lactones found primarily in fungi, frogs, and termites is presented. The following chapter presents the development of the intriguing plant-derived sesquiterpene lactone, thapsigargin, a potent inhibitor of the enzyme, SERCA (sarco-endoplasmic Ca2+ ATPase), which has potential as a lead compound to treat cancer. The third chapter covers the potential of various plant phenolic compounds for treating the tropical and sub-tropical infectious disease, leishmaniasis. In addition the volume presents recent advances related to the plant alkaloid, cryptolepine, which is of particular interest as a lead for the treatment of malaria, trypanosomiasis, and cancer.
Kinghorn, A. Douglas
Falk, Heinz
Gibbons, Simon
Asakawa, Yoshinori
Liu, Ji-Kai
Dirsch, Verena M
| ISBN | 9783030648534 |
|---|---|
| Article number | 9783030648534 |
| Media type | eBook - PDF |
| Copyright year | 2021 |
| Publisher | Springer-Verlag |
| Length | 203 pages |
| Language | English |
| Copy protection | Digital watermarking |
