Science of Synthesis: Houben-Weyl Methods of Molecular Transformations is the entirely new edition of the acclaimed reference series Houben-Weyl, the standard synthetic chemistry resource since 1909. This new edition is published in English and will comprise 48 volumes published between the years 2000 and 2008.

Science of Synthesis is a quality reference work developed by a highly esteemed editorial board to provide a comprehensive and critical selection of reliable organic and organometallic synthetic methods. This unique resource is designed to be the first point of reference when searching for a synthesis strategy.

• Contains the expertise of presently 400 leading chemists worldwide
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• Discusses relevant background information and provides detailed experimental procedures

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1;Science of Synthesis - Volume 18: Four Carbon--Heteroatom Bonds: X--C=X, X==C==X, X2C==X, CX4;11.1;Title page;31.2;Imprint;51.3;Preface;61.4;Volume Editor's Preface;81.5;Overview;101.6;Table of Contents;121.7;Introduction;581.8;18.1 Product Class 1: Cyanogen Halides, Cyanates and Their Sulfur, Selenium, and Tellurium Analogues, Sulfinyl and Sulfonyl Cyanides, Cyanamides, and Phosphaalkynes;741.8.1;18.1.1 Product Subclass 1: Cyanogen Halides;741.8.1.1;18.1.1.1 Synthesis of Product Subclass 1;741.8.1.1.1;18.1.1.1.1 Method 1: By Halogenation of Cyanides;741.8.1.1.2;18.1.1.1.2 Method 2: Cyanogen Fluoride by Pyrolysis of 2,4,6-Trifluoro-1,3,5-triazine;751.8.1.2;18.1.1.2 Applications of Product Subclass 1 in Organic Synthesis;761.8.1.2.1;18.1.1.2.1 Method 1: Cleavage of Carbon--Heteroatom Bonds;761.8.1.2.2;18.1.1.2.2 Method 2: Formation of Heterocyclic Rings;771.8.1.2.3;18.1.1.2.3 Method 3: As Cyanating Reagents;781.8.2;18.1.2 Product Subclass 2: Cyanates and Their Sulfur, Selenium, and Tellurium Analogues;791.8.2.1;18.1.2.1 Synthesis of Product Subclass 2;791.8.2.1.1;18.1.2.1.1 Method 1: By Nucleophilic Reactions from Cyanate Salts;791.8.2.1.2;18.1.2.1.2 Method 2: By Cyanation;811.8.2.1.2.1;18.1.2.1.2.1 Variation 1: Of Alcohols, Phenols, and Related Compounds with Cyanogen Halides;811.8.2.1.2.2;18.1.2.1.2.2 Variation 2: Of Halogenated Precursors with Cyanides;821.8.2.1.2.3;18.1.2.1.2.3 Variation 3: Thiocyanates from Sodium Sulfinates or Sulfonyl Chlorides;831.8.2.1.3;18.1.2.1.3 Method 3: Thiocyanates and Selenocyanates from Trimethylsilyl Isothiocyanates and Isoselenocyanates;841.8.2.1.4;18.1.2.1.4 Method 4: Thiocyanates and Selenocyanates from Thiocyanogen and Selenocyanogen;851.8.2.2;18.1.2.2 Applications of Product Subclass 2 in Organic Synthesis;871.8.2.2.1;18.1.2.2.1 Method 1: Formation of Heterocyclic Compounds;871.8.2.2.2;18.1.2.2.2 Method 2: Cyanates and Thiocyanates as Cyanating Reagents;871.8.2.2.3;18.1.2.2.3 Method 3: Addition of Thiocyanates or Selenocyanates to Aldehydes and Alkene Double Bonds;881.8.3;18.1.3 Product Subclass 3: Sulfinyl and Sulfonyl Cyanides;901.8.3.1;18.1.3.1 Synthesis of Product Subclass 3;901.8.3.1.1;18.1.3.1.1 Method 1: By Oxidation of Thiocyanates;901.8.3.1.2;18.1.3.1.2 Method 2: By Cyanation of Sulfinate Salts and Sulfonyl Chlorides;911.8.3.2;18.1.3.2 Applications of Product Subclass 3 in Organic Synthesis;911.8.3.2.1;18.1.3.2.1 Method 1: Sulfonyl Cyanides as Cyanating Reagents;911.8.3.2.2;18.1.3.2.2 Method 2: Formation of Heterocyclic Compounds from Sulfonyl Cyanides;921.8.4;18.1.4 Product Subclass 4: Cyanamides and Their Derivatives;931.8.4.1;18.1.4.1 Synthesis of Product Subclass 4;941.8.4.1.1;18.1.4.1.1 Method 1: By Alkylation of Cyanamide;941.8.4.1.2;18.1.4.1.2 Method 2: By Cyanation of Amines;951.8.4.1.2.1;18.1.4.1.2.1 Variation 1: With Cyanogen Halides;951.8.4.1.2.2;18.1.4.1.2.2 Variation 2: With Other Cyanating Reagents;951.8.4.1.2.3;18.1.4.1.2.3 Variation 3: By Cyanation of Halo Amines with Cyanides;961.8.4.1.3;18.1.4.1.3 Method 3: By Elimination from Ureas and Thioureas;971.8.4.1.4;18.1.4.1.4 Method 4: By Rearrangement Reactions;971.8.4.1.4.1;18.1.4.1.4.1 Variation 1: From Amidoximes by a Modified Tiemann Rearrangement;981.8.4.1.4.2;18.1.4.1.4.2 Variation 2: From N,N-Disubstituted Formamides by a Curtius-like Rearrangement;991.8.4.1.4.3;18.1.4.1.4.3 Variation 3: By Palladium-Catalyzed Coupling of Isocyanides, Allyl Carbonate, and Trimethylsilyl Azide through a Curtius-like Rearrangement;991.8.4.1.5;18.1.4.1.5 Method 5: By Decomposition of Heterocyclic Compounds;1001.8.4.1.6;18.1.4.1.6 Method 6: Palladium-Catalyzed Formation of N,N-Diallyl Cyanamides;1021.8.4.1.7;18.1.4.1.7 Method 7: Lewis Acid Catalyzed Reactions of Carbonyl Groups with N,N'-Bis(trimethylsilyl)carbodiimide;1031.8.4.2;18.1.4.2 Applications of Product Subclass 4 in Organic Synthesis;1031.8.4.2.1;18.1.4.2.1 Method 1: Forma