Science of Synthesis: Houben-Weyl Methods of Molecular Transformations is the entirely new edition of the acclaimed reference series Houben-Weyl, the standard synthetic chemistry resource since 1909. This new edition is published in English and will comprise 48 volumes published between the years 2000 and 2008.

Science of Synthesis is a quality reference work developed by a highly esteemed editorial board to provide a comprehensive and critical selection of reliable organic and organometallic synthetic methods. This unique resource is designed to be the first point of reference when searching for a synthesis strategy.

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1;Science of Synthesis - Volume 30: Acetals: O/N, S/S, S/N, and N/N and Higher Heteroatom Analogues;11.1;Title page;31.2;Imprint;51.3;Preface;61.4;Overview;81.5;Table of Contents;101.6;Introduction;261.7;30.1 Product Class 1: O,N-Acetals;321.7.1;30.1.1 Product Subclass 1: Acyclic O,N-Acetals;321.7.1.1;30.1.1.1 Synthesis of Product Subclass 1;331.7.1.1.1;30.1.1.1.1 Method 1: Addition to Imine Bonds;331.7.1.1.2;30.1.1.1.2 Method 2: Addition to Carbonyl Bonds;341.7.1.1.2.1;30.1.1.1.2.1 Variation 1: Addition of Amines to Carbonyl Bonds;341.7.1.1.2.2;30.1.1.1.2.2 Variation 2: Addition of Carbanions to Carbonyl Bonds;351.7.1.1.2.3;30.1.1.1.2.3 Variation 3: Addition of Hydrides to Carbonyl Bonds;351.7.1.1.3;30.1.1.1.3 Method 3: Transacetalization Reactions;361.7.1.1.4;30.1.1.1.4 Methods 4: Miscellaneous Syntheses;371.7.1.2;30.1.1.2 Applications of Product Subclass 1 in Organic Synthesis;391.7.1.2.1;30.1.1.2.1 Method 1: Preparation of Acyclic Compounds via C--C Bond Formation with Cleavage of a C--O Bond;391.7.1.2.2;30.1.1.2.2 Method 2: Preparation of Cyclic Compounds via C--C Bond Formation with Cleavage of a C--O Bond;411.7.1.2.3;30.1.1.2.3 Methods 3: Miscellaneous Transformations;421.7.2;30.1.2 Product Subclass 2: Cyclic O,N-Acetals;461.7.2.1;30.1.2.1 Synthesis of Product Subclass 2;461.7.2.1.1;30.1.2.1.1 Method 1: Addition to Imine Bonds;461.7.2.1.2;30.1.2.1.2 Method 2: Addition to Carbonyl Bonds;471.7.2.1.2.1;30.1.2.1.2.1 Variation 1: Addition of Hydrides to Carbonyl Bonds;471.7.2.1.2.2;30.1.2.1.2.2 Variation 2: Addition of Amines to Carbonyl Bonds;491.7.2.1.2.3;30.1.2.1.2.3 Variation 3: Addition of Silirane to Carbonyl Bonds;491.7.2.1.3;30.1.2.1.3 Method 3: O,N-Acetalization of Carbonyl Compounds;491.7.2.1.3.1;30.1.2.1.3.1 Variation 1: Acetalization of Carbonyl Compounds with 8-Aminomenthol;501.7.2.1.3.2;30.1.2.1.3.2 Variation 2: Acetalization of Carbonyl Compounds with (S)-Proline;501.7.2.1.3.3;30.1.2.1.3.3 Variation 3: Acetalization of Carbonyl Compounds with (Hydroxymethyl)pyrrolidinone;501.7.2.1.3.4;30.1.2.1.3.4 Variation 4: Acetalization of Carbonyl Compounds with N-Mesylalanine;511.7.2.1.3.5;30.1.2.1.3.5 Variation 5: Acetalization of Carbonyl Compounds with Phenylglycinol;511.7.2.1.3.6;30.1.2.1.3.6 Variation 6: Acetalization of Carbonyl Compounds with Aminophenols;531.7.2.1.4;30.1.2.1.4 Method 4: Preparation of O,N-Acetals via Transacetalization;541.7.2.1.4.1;30.1.2.1.4.1 Variation 1: Via Intermolecular Transacetalization;541.7.2.1.4.2;30.1.2.1.4.2 Variation 2: Via Intramolecular Transacetalization;561.7.2.1.5;30.1.2.1.5 Methods 5: Miscellaneous Methods;571.7.2.1.5.1;30.1.2.1.5.1 Variation 1: Preparation of O,N-Acetals by Oxidation;571.7.2.1.5.2;30.1.2.1.5.2 Variation 2: Addition of Alcohols to Alkenyl Bonds;581.7.2.1.5.3;30.1.2.1.5.3 Variation 3: Addition of Amines to Alkenyl Bonds;591.7.2.1.5.4;30.1.2.1.5.4 Variation 4: Nucleophilic Substitution of Alcohols;591.7.2.2;30.1.2.2 Applications of Product Subclass 2 in Organic Synthesis;601.7.2.2.1;30.1.2.2.1 Method 1: Preparation of Acyclic Compounds via C--C Bond Formation with Cleavage of a C--O Bond;601.7.2.2.2;30.1.2.2.2 Method 2: Preparation of Cyclic Compounds via C--C Bond Formation with Cleavage of a C--O Bond;601.7.2.2.2.1;30.1.2.2.2.1 Variation 1: C--C Bond Formation Using Organometallic Reagents;601.7.2.2.2.2;30.1.2.2.2.2 Variation 2: C--C Bond Formation Using Allyltrimethylsilane;621.7.2.2.2.3;30.1.2.2.2.3 Variation 3: Insertion of Internal p-Nucleophiles;631.7.2.2.3;30.1.2.2.3 Method 3: Reductive Cleavage of the C--O Bond;641.7.2.2.3.1;30.1.2.2.3.1 Variation 1: Reductive Cleavage by Hydrogenation;651.7.2.2.3.2;30.1.2.2.3.2 Variation 2: Reductive Cleavage with Bis(2-methoxyethoxy)aluminum Hydride;651.7.2.2.3.3;30.1.2.2.3.3 Variation 3: Reductive Cleavage with Sodium Borohydride--Boron Trifluoride--Diethyl Ether Complex;661.7.2.2.3.4;30.1.2.2.3.4 Variation 4: Reducti