Science of Synthesis: Houben-Weyl Methods of Molecular Transformations is the entirely new edition of the acclaimed reference series Houben-Weyl, the standard synthetic chemistry resource since 1909. This new edition is published in English and will comprise 48 volumes published between the years 2000 and 2008.

Science of Synthesis is a quality reference work developed by a highly esteemed editorial board to provide a comprehensive and critical selection of reliable organic and organometallic synthetic methods. This unique resource is designed to be the first point of reference when searching for a synthesis strategy.

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• Discusses relevant background information and provides detailed experimental procedures

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1;Science of Synthesis - Volume 31a: Arene--X (X = Hal, O, S, Se, Te);11.1;Title page;31.2;Imprint;51.3;Preface;61.4;Volume Editor's Preface;81.5;Overview;101.6;Table of Contents;141.7;Introduction;521.8;31.1 Product Class 1: Fluoroarenes;721.8.1;31.1.1 Synthesis of Product Class 1;751.8.1.1;31.1.1.1 Synthesis by Substitution of Hydrogen;751.8.1.1.1;31.1.1.1.1 Method 1: Direct Fluorination with Elemental Fluorine;751.8.1.1.2;31.1.1.1.2 Method 2: Reaction with Electrophilic N--F Reagents;821.8.1.1.2.1;31.1.1.1.2.1 Variation 1: With 1-Fluoropyridinium Salts;821.8.1.1.2.2;31.1.1.1.2.2 Variation 2: With 1-(Chloromethyl)-4-fluoro-1,4-diazoniabicyclo[2.2.2]octane Bis(tetrafluoroborate);851.8.1.1.2.3;31.1.1.1.2.3 Variation 3: With Other Electrophilic N--F Reagents;861.8.1.1.3;31.1.1.1.3 Method 3: Reaction with Xenon Difluoride;871.8.1.1.4;31.1.1.1.4 Method 4: Reaction with Organic Hypofluorites;881.8.1.1.5;31.1.1.1.5 Method 5: Reaction with Cesium Fluoroxysulfate;921.8.1.2;31.1.1.2 Synthesis by Substitution of Organometallic Groups;931.8.1.2.1;31.1.1.2.1 Method 1: Reaction of Aryllithium Derivatives;931.8.1.2.2;31.1.1.2.2 Method 2: Reaction of Phenylmagnesium Halides;941.8.1.2.3;31.1.1.2.3 Method 3: Reactions of Aryl--Group 14 Derivatives;951.8.1.3;31.1.1.3 Synthesis by Substitution of Halogen Atoms;961.8.1.3.1;31.1.1.3.1 Method 1: Reaction with Alkali Metal Fluorides;971.8.1.4;31.1.1.4 Synthesis by Substitution of Sulfur;1031.8.1.4.1;31.1.1.4.1 Method 4: Reaction of Sulfonyl Derivatives;1031.8.1.5;31.1.1.5 Synthesis by Substitution of Nitrogen;1041.8.1.5.1;31.1.1.5.1 Method 1: Replacement of Nitro Groups;1041.8.1.5.1.1;31.1.1.5.1.1 Variation 1: Reaction with Potassium Fluoride;1041.8.1.5.1.2;31.1.1.5.1.2 Variation 2: Reaction with Tetraalkylammonium Fluorides;1071.8.1.5.2;31.1.1.5.2 Method 2: Replacement of Diazo Groups;1071.8.1.5.2.1;31.1.1.5.2.1 Variation 1: Reaction with Hydrogen Fluoride;1081.8.1.5.2.2;31.1.1.5.2.2 Variation 2: Reaction with Hydrogen Fluoride/Pyridine Mixtures;1091.8.1.5.2.3;31.1.1.5.2.3 Variation 3: Reaction of Diazonium Tetrafluoroborates;1121.8.1.5.2.4;31.1.1.5.2.4 Variation 4: Reaction of Diazonium Hexafluoroantimonates;1141.8.1.5.2.5;31.1.1.5.2.5 Variation 5: Reaction with Nitrosonium Tetrafluoroborate;1151.8.1.5.2.6;31.1.1.5.2.6 Variation 6: Reaction of Triazenes;1161.8.1.6;31.1.1.6 Synthesis by Elimination;1171.8.1.6.1;31.1.1.6.1 Method 1: Elimination of Hydrogen Fluoride;1171.8.1.6.2;31.1.1.6.2 Method 2: Elimination of Fluorine;1171.8.1.7;31.1.1.7 Synthesis with Retention of Fluorine;1191.8.1.7.1;31.1.1.7.1 Method 1: Reactions of Fluoroarenes;1191.8.1.7.2;31.1.1.7.2 Method 2: Reactions of Perfluoroarenes;1211.9;31.2 Product Class 2: Chloroarenes;1301.9.1;31.2.1 Synthesis of Product Class 2;1301.9.1.1;31.2.1.1 Synthesis by Substitution;1301.9.1.1.1;31.2.1.1.1 Method 1: Electrophilic Chlorination;1311.9.1.1.1.1;31.2.1.1.1.1 Variation 1: Of Phenols and Anisoles;1311.9.1.1.1.2;31.2.1.1.1.2 Variation 2: Of Anilines and Acetanilides;1331.9.1.1.1.3;31.2.1.1.1.3 Variation 3: Of Alkylbenzenes;1351.9.1.1.1.4;31.2.1.1.1.4 Variation 4: Of Polycyclic Aromatics;1361.9.1.1.2;31.2.1.1.2 Method 2: The Sandmeyer Reaction;1371.9.1.1.3;31.2.1.1.3 Method 3: Substitution of a Nitro Group;1381.9.1.1.4;31.2.1.1.4 Method 4: Substitution of a Phenolic Hydroxy Group;1391.9.1.2;31.2.1.2 Synthesis by Elimination;1401.9.1.2.1;31.2.1.2.1 Method 1: Dehydrohalogenation;1401.9.1.2.2;31.2.1.2.2 Method 2: Dehalogenation;1411.9.1.2.3;31.2.1.2.3 Method 3: Pyrolytic Loss of a Small Molecule;1421.9.1.2.4;31.2.1.2.4 Method 4: Transition-Metal-Catalyzed Decarbonylation;1431.9.1.3;31.2.1.3 Synthesis by Cycloaddition;1441.9.1.3.1;31.2.1.3.1 Method 1: Cycloadditions Reactions of Tetrachlorothiophene Dioxide;1451.9.1.3.2;31.2.1.3.2 Method 2: Cobalt-Catalyzed Reactions;1461.9.1.4;31.2.1.4 Synthesis by Rearrangement;1461.9.1.4.1;31.2