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Science of Synthesis: Houben-Weyl Methods of Molecular Transformations is the entirely new edition of the acclaimed reference series Houben-Weyl, the standard synthetic chemistry resource since 1909. This new edition is published in English and will comprise 48 volumes published between the years 2000 and 2008.

Science of Synthesis is a quality reference work developed by a highly esteemed editorial board to provide a comprehensive and critical selection of reliable organic and organometallic synthetic methods. This unique resource is designed to be the first point of reference when searching for a synthesis strategy.

• Contains the expertise of presently 400 leading chemists worldwide
• Critically evaluates the preparative applicability and significance of the synthetic methods
• Discusses relevant background information and provides detailed experimental procedures

For full information on the Science of Synthesis series, visit the Science of Synthesis Homepage

1;Volume 40a: Amines and Ammonium Salts;11.1;Title page;31.2;Imprint;51.3;Preface;61.4;Volume Editors Preface;81.5;Overview;101.6;Table of Contents;121.7;Introduction;301.8;40.1 Product Class 1: Amino Compounds;361.8.1;40.1.1 Product Subclass 1: Alkyl- and Cycloalkylamines;361.8.1.1;40.1.1.1 Synthesis by Reduction;521.8.1.1.1;40.1.1.1.1 Reduction of Carbonic and Carboxylic Acid Derivatives;521.8.1.1.1.1;40.1.1.1.1.1 Method 1: Reduction of Carbon Monoxide Gas;521.8.1.1.1.2;40.1.1.1.1.2 Method 2: Reduction of Carbamates;521.8.1.1.1.2.1;40.1.1.1.1.2.1 Variation 1: Reduction with Aluminum Hydrides;531.8.1.1.1.2.2;40.1.1.1.1.2.2 Variation 2: Catalytic Hydrogenation;541.8.1.1.1.2.3;40.1.1.1.1.2.3 Variations 3: Miscellaneous Reductions;561.8.1.1.1.3;40.1.1.1.1.3 Method 3: Reduction of Isocyanates or Isothiocyanates;571.8.1.1.1.4;40.1.1.1.1.4 Method 4: Reduction of Nitriles;581.8.1.1.1.4.1;40.1.1.1.1.4.1 Variation 1: Catalytic Hydrogenation;581.8.1.1.1.4.2;40.1.1.1.1.4.2 Variation 2: Reduction with Aluminum Hydrides;631.8.1.1.1.4.3;40.1.1.1.1.4.3 Variation 3: Reduction with Boranes;671.8.1.1.1.4.4;40.1.1.1.1.4.4 Variation 4: Reduction with Borohydrides;701.8.1.1.1.4.5;40.1.1.1.1.4.5 Variation 5: The Kulinkovich--de Meijere Reaction;731.8.1.1.1.5;40.1.1.1.1.5 Method 5: Reduction of Amides or Thioamides;741.8.1.1.1.5.1;40.1.1.1.1.5.1 Variation 1: Reduction with Aluminum Hydrides;741.8.1.1.1.5.2;40.1.1.1.1.5.2 Variation 2: Reduction with Borane Derivatives;771.8.1.1.1.5.3;40.1.1.1.1.5.3 Variation 3: Reduction with Hydrosilanes;781.8.1.1.1.5.4;40.1.1.1.1.5.4 Variation 4: Reduction of Thioamides;791.8.1.1.1.5.5;40.1.1.1.1.5.5 Variation 5: The Kulinkovich--de Meijere Reaction;801.8.1.1.1.6;40.1.1.1.1.6 Method 6: Reduction of Imides;831.8.1.1.1.7;40.1.1.1.1.7 Method 7: Reduction of Imidates and Imidoyl Chlorides;841.8.1.1.2;40.1.1.1.2 Reductive Amination of Carbonyl Compounds;941.8.1.1.2.1;40.1.1.1.2.1 Alkylamines from Carbonyl Compounds by Direct Reductive Amination;941.8.1.1.2.1.1;40.1.1.1.2.1.1 Method 1: Direct Reductive Amination by Catalytic Hydrogenation;951.8.1.1.2.1.1.1;40.1.1.1.2.1.1.1 Variation 1: Hydrogenation Using Heterogeneous Metal Catalysts;951.8.1.1.2.1.1.2;40.1.1.1.2.1.1.2 Variation 2: Hydrogenation Using Homogeneous Metal Complex Catalysts;961.8.1.1.2.1.1.3;40.1.1.1.2.1.1.3 Variation 3: Palladium-Catalyzed Transfer Hydrogenation;971.8.1.1.2.1.2;40.1.1.1.2.1.2 Method 2: Direct Reductive Amination Using Silanes as a Hydrogen Source;981.8.1.1.2.1.2.1;40.1.1.1.2.1.2.1 Variation 1: Using Polymethylhydrosiloxane;981.8.1.1.2.1.2.2;40.1.1.1.2.1.2.2 Variation 2: Using Aminohydrosilanes;981.8.1.1.2.1.2.3;40.1.1.1.2.1.2.3 Variation 3: Using Triethylsilane;991.8.1.1.2.1.3;40.1.1.1.2.1.3 Method 3: Direct Reductive Amination with Borohydride or Borane Reducing Agents;991.8.1.1.2.1.3.1;40.1.1.1.2.1.3.1 Variation 1: Using Sodium Cyanoborohydride;991.8.1.1.2.1.3.2;40.1.1.1.2.1.3.2 Variation 2: Using Sodium Borohydride;1011.8.1.1.2.1.3.3;40.1.1.1.2.1.3.3 Variation 3: Using Zirconium(II) or Copper(I) Borohydrides;1021.8.1.1.2.1.3.4;40.1.1.1.2.1.3.4 Variation 4: Using Sodium Triacyloxyborohydrides;1031.8.1.1.2.1.3.5;40.1.1.1.2.1.3.5 Variation 5: Using Aminoboranes;1031.8.1.1.2.2;40.1.1.1.2.2 Primary Alkylamines from Oximes and O-Alkyloximes;1041.8.1.1.2.2.1;40.1.1.1.2.2.1 Primary Alkylamines from Oximes;1051.8.1.1.2.2.1.1;40.1.1.1.2.2.1.1 Method 1: Catalytic Hydrogenation;1051.8.1.1.2.2.1.2;40.1.1.1.2.2.1.2 Method 2: Catalytic Transfer Hydrogenation;1061.8.1.1.2.2.1.3;40.1.1.1.2.2.1.3 Method 3: Reduction with Metallic Zinc;1061.8.1.1.2.2.1.3.1;40.1.1.1.2.2.1.3.1 Variation 1: Using Zinc in the Presence of Ammonia;1061.8.1.1.2.2.1.3.2;40.1.1.1.2.2.1.3.2 Variation 2: Using Zinc in the Presence of a Carboxylic Acid;1071.8.1.1.2.2.1.4;40.1.1.1.2.2.1.4 Method 4: Reductions with Borane or Borohydrides;1081.8.1.1.2.2.1.4.1;40.1.1.1.2.2.1.4.1 Vari