Science of Synthesis: Houben-Weyl Methods of Molecular Transformations is the entirely new edition of the acclaimed reference series Houben-Weyl, the standard synthetic chemistry resource since 1909. This new edition is published in English and will comprise 48 volumes published between the years 2000 and 2008.

Science of Synthesis is a quality reference work developed by a highly esteemed editorial board to provide a comprehensive and critical selection of reliable organic and organometallic synthetic methods. This unique resource is designed to be the first point of reference when searching for a synthesis strategy.

• Contains the expertise of presently 400 leading chemists worldwide
• Critically evaluates the preparative applicability and significance of the synthetic methods
• Discusses relevant background information and provides detailed experimental procedures

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1;Science of Synthesis - Volume 48: Alkanes;11.1;Title page;31.2;Imprint;51.3;Preface;61.4;Overview;81.5;Table of Contents;101.6;Introduction;241.7;48.1 Product Class 1: Acyclic Alkanes;321.7.1;48.1.1 Synthesis by Metal Substitution with Retention of the Carbon Framework;321.7.1.1;48.1.1.1 Method 1: Synthesis by Protonation of Carbon--Metal Bonds;321.7.1.1.1;48.1.1.1.1 Variation 1: Acidolysis of Alkyl Derivatives of Metals from Groups 14 and 15 (Including Boron);331.7.1.1.2;48.1.1.1.2 Variation 2: Protonolysis of Alkyl Derivatives of Metals from Groups 5--11;371.7.1.1.3;48.1.1.1.3 Variation 3: Protonolysis of Alkyl Derivatives of Metals from Groups 3, 4, 12, and 13 (Including Lanthanides and Actinides, Excluding Boron);381.7.1.1.4;48.1.1.1.4 Variation 4: Protonolysis of Alkyl Derivatives of Metals from Groups 1 and 2;411.7.1.2;48.1.1.2 Method 2: Synthesis by Hydrogenolysis of Carbon--Metal Bonds;461.7.1.2.1;48.1.1.2.1 Variation 1: Hydrogenolysis and Reductive Cleavage of Carbon--Metal Bonds;461.7.1.2.2;48.1.1.2.2 Variation 2: Reductive Elimination from Alkyl--Transition Metal Hydrido Complexes;481.7.2;48.1.2 Synthesis by Metal Substitution with Extension of the Carbon Framework;521.7.2.1;48.1.2.1 Method 1: Noncatalyzed Coupling Reactions of Nonactivated Alkyl Electrophiles with Organometallic Reagents;531.7.2.1.1;48.1.2.1.1 Variation 1: Using Main-Group Organometallic Reagents;531.7.2.1.2;48.1.2.1.2 Variation 2: Using Transition-Metal Organometallic Reagents;551.7.2.2;48.1.2.2 Method 2: Catalyzed Coupling Reactions of Nonactivated Alkyl Electrophiles with Organometallic Reagents;591.7.2.2.1;48.1.2.2.1 Variation 1: Couplings of Alkyl Grignard Reagents (Kumada--Tamao--Corriu Reaction) Mediated by Copper, Silver, Nickel, Palladium, Iron, and Cobalt;611.7.2.2.2;48.1.2.2.2 Variation 2: Couplings of Alkylzinc Reagents (Negishi Reaction) Mediated by Nickel and Palladium;741.7.2.2.3;48.1.2.2.3 Variation 3: Couplings of Alkyl Boron Compounds (Suzuki--Miyaura Reaction) Mediated by Palladium and Nickel;861.7.2.2.4;48.1.2.2.4 Variation 4: Couplings of Other Alkyl Organometallic Compounds;991.7.2.3;48.1.2.3 Method 3: Oxidative Coupling of Alkyl Organometallic Reagents;1001.7.2.3.1;48.1.2.3.1 Variation 1: Reductive Elimination from Dialkyl Transition-Metal Complexes;1061.7.2.3.2;48.1.2.3.2 Variation 2: Kolbe Electrolysis;1081.7.2.4;48.1.2.4 Method 4: Reductive Coupling of Alkyl Halides;1101.7.3;48.1.3 Synthesis by Reduction without C--C Bond Cleavage;1201.7.3.1;48.1.3.1 Reduction of Carbonic or Carboxylic Acids, Aldehydes, Ketones, or Derivatives;1201.7.3.1.1;48.1.3.1.1 Method 1: The Clemmensen Reduction (Deoxygenation of Aldehydes or Ketones Using Zinc and Hydrochloric Acid);1221.7.3.1.1.1;48.1.3.1.1.1 Variation 1: Reduction with Zinc--Hydrochloric Acid in an Aqueous Solution;1231.7.3.1.1.2;48.1.3.1.1.2 Variation 2: Reduction with Zinc--Hydrochloric Acid in the Presence of Water-Miscible Solvents;1241.7.3.1.1.3;48.1.3.1.1.3 Variation 3: Reduction with Zinc--Hydrochloric Acid in the Presence of Water-Immiscible Solvents;1251.7.3.1.1.4;48.1.3.1.1.4 Variation 4: Reduction with Zinc in Organic Solvents Saturated with Hydrogen Chloride;1251.7.3.1.1.5;48.1.3.1.1.5 Variation 5: Ultrasound-Assisted Zinc--Protic Acid Reduction;1271.7.3.1.1.6;48.1.3.1.1.6 Variation 6: Miscellaneous Methods;1271.7.3.1.2;48.1.3.1.2 Method 2: Other Direct Deoxygenation Methods;1281.7.3.1.2.1;48.1.3.1.2.1 Variation 1: Deoxygenation of Aromatic Ketones with Hydrogen Iodide;1281.7.3.1.2.2;48.1.3.1.2.2 Variation 2: Deoxygenation of Carbonyl Compounds by Catalytic Hydrogenation;1281.7.3.1.2.3;48.1.3.1.2.3 Variation 3: Deoxygenation of Aromatic Acids, Aldehydes, and Ketones Using the Trichlorosilane--Tripropylamine Couple;1291.7.3.1.2.4;48.1.3.1.2.4 Variation 4: Deoxygenation of Ketones Using the Triethylsilane--Trifluoroacetic Acid Couple;1301.7.3.1.2.5;48.1.3.1.2.5 Variation 5: Deoxygenation