Science of Synthesis: Houben-Weyl Methods of Molecular Transformations is the entirely new edition of the acclaimed reference series Houben-Weyl, the standard synthetic chemistry resource since 1909. This new edition is published in English and will comprise 48 volumes published between the years 2000 and 2008.

Science of Synthesis is a quality reference work developed by a highly esteemed editorial board to provide a comprehensive and critical selection of reliable organic and organometallic synthetic methods. This unique resource is designed to be the first point of reference when searching for a synthesis strategy.

• Contains the expertise of presently 400 leading chemists worldwide
• Critically evaluates the preparative applicability and significance of the synthetic methods
• Discusses relevant background information and provides detailed experimental procedures

For full information on the Science of Synthesis series, visit the Science of Synthesis Homepage

1;Science of Synthesis - Volume 8b: Compounds of Group 1 (Li...Cs);11.1;Title page;31.2;Imprint;51.3;Preface;61.4;Overview;121.5;Table of Contents;161.6;Introduction;381.7;8.2 Product Class 2: Sodium Compounds;541.7.1;8.2.1 Product Subclass 1: Sodium Metal and Sodium--Potassium Alloy;561.7.1.1;Applications of Product Subclass 1 in Organic Synthesis;561.7.1.1.1;8.2.1.1 Method 1: Reduction of Carbon--Heteroatom Multiple Bonds;561.7.1.1.1.1;8.2.1.1.1 Variation 1: Ketone Reduction in Protic Conditions;571.7.1.1.1.2;8.2.1.1.2 Variation 2: Ketone Reduction in Liquid Ammonia;581.7.1.1.1.3;8.2.1.1.3 Variation 3: Bimolecular Reduction of Carbonyl Groups (Pinacol Coupling);581.7.1.1.1.4;8.2.1.1.4 Variation 4: Reduction of Esters;591.7.1.1.1.5;8.2.1.1.5 Variation 5: Reduction of Amides;601.7.1.1.1.6;8.2.1.1.6 Variation 6: Reduction of Enones;611.7.1.1.1.7;8.2.1.1.7 Variation 7: Reduction of Nitriles;621.7.1.1.1.8;8.2.1.1.8 Variation 8: Reduction of 1,3-Diimines;621.7.1.1.2;8.2.1.2 Method 2: Reduction of C--C Multiple Bonds;621.7.1.1.2.1;8.2.1.2.1 Variation 1: Hydrogenation of C==C Bonds;621.7.1.1.2.2;8.2.1.2.2 Variation 2: Hydrogenation of Alkynes;641.7.1.1.3;8.2.1.3 Method 3: Reduction of Carbon--Heteroatom Single Bonds;641.7.1.1.3.1;8.2.1.3.1 Variation 1: Dehalogenation of Alkyl Halides;641.7.1.1.3.2;8.2.1.3.2 Variation 2: Cleavage of Esters and Ethers;651.7.1.1.3.3;8.2.1.3.3 Variation 3: Cleavage of C--S Bonds;661.7.1.1.4;8.2.1.4 Method 4: Reduction of C--C Single Bonds;671.7.1.1.4.1;8.2.1.4.1 Variation 1: Decyanation;671.7.2;8.2.2 Product Subclass 2: Sodium Hydride;701.7.2.1;Synthesis of Product Subclass 2;701.7.2.1.1;8.2.2.1 Method 1: Preparation of Sodium Hydride;701.7.2.2;Applications of Product Subclass 2 in Organic Synthesis;711.7.2.2.1;8.2.2.2 Method 2: Metalation of the Hydroxy Group;711.7.2.2.1.1;8.2.2.2.1 Variation 1: Etherification in the Presence of 15-Crown-5;711.7.2.2.1.2;8.2.2.2.2 Variation 2: Etherification with Superactive Sodium Hydride;721.7.2.2.1.3;8.2.2.2.3 Variation 3: Etherification on Solid Support;721.7.2.2.1.4;8.2.2.2.4 Variation 4: Base-Promoted Cyclization of Hydroxy Propargylic Sulfones;731.7.2.2.1.5;8.2.2.2.5 Variation 5: Formation of Highly Substituted Diphenyl Carbonates;741.7.2.2.2;8.2.2.3 Method 3: Alkylation of Amines and Amides;751.7.2.2.2.1;8.2.2.3.1 Variation 1: Transformation of Dihydroimidazoles into 2,4,6-Trisubstituted Pyrimidines;761.7.2.2.3;8.2.2.4 Method 4: Metalation of C--H Groups;771.7.2.2.3.1;8.2.2.4.1 Variation 1: Trapping of a-Lactams by Weak Nuclephiles;771.7.2.2.3.2;8.2.2.4.2 Variation 2: Synthesis of Ylides;781.7.2.2.3.3;8.2.2.4.3 Variation 3: Base-Promoted Cyclization of Alkynones;801.7.2.2.3.4;8.2.2.4.4 Variation 4: Dieckmann Condensation;801.7.2.2.3.5;8.2.2.4.5 Variation 5: The Darzens Reaction;811.7.2.2.3.6;8.2.2.4.6 Variation 6: Synthesis of .-Oxo Acids;811.7.2.2.3.7;8.2.2.4.7 Variation 7: Synthesis of 1,3-Diketones;821.7.2.2.3.8;8.2.2.4.8 Variation 8: Tandem Michael--Dieckmann Synthesis of Carbocycles;831.7.2.2.3.9;8.2.2.4.9 Variation 9: Double Annulation Leading to Fused Bicyclic Compounds;831.7.2.2.3.10;8.2.2.4.10 Variation 10: a-Alkylation of Sulfones;841.7.2.2.3.11;8.2.2.4.11 Variation 11: Regiocontrolled Synthetic Approach to Unsymmetrical Ketones;851.7.2.2.3.12;8.2.2.4.12 Variation 12: Allylation of Alkenylidenemalonate;861.7.2.2.3.13;8.2.2.4.13 Variation 13: Base-Induced Cycloaddition;871.7.2.2.3.14;8.2.2.4.14 Variation 14: Asymmetric Addition of Malonate Nucleophiles;871.7.2.2.3.15;8.2.2.4.15 Variation 15: Cyclization of Phenylacetonitriles;881.7.2.2.4;8.2.2.5 Method 5: Reduction of Carbon--Heteroatom Multiple Bonds;891.7.2.2.4.1;8.2.2.5.1 Variation 1: Reduction of Tosylhydrazones;891.7.2.2.4.2;8.2.2.5.2 Variation 2: Reduction Using Metal-Containing Complex Reducing Agents;891.7.2.2.5;8.2.2.6 Method 6: Reduction of C--C Multiple Bonds;921.7.2.2.6;8.2.2.7 Meth