Protein phosphorylation is an essential post-translational modification that modulates cell-cell communication. Substrate phosphorylation by protein kinases controls intracellular signal transduction pathways that mediate cell proliferation, migration, differentiation, and metabolism. The importance of the protein kinase family is underscored by numerous disease states that arise due to dysregulation of kinase activity. Recent progress in understanding the molecular regulation of kinases has led to the development of new therapeutics based on the inhibition of kinase activity. Inhibitors that target protein kinases have proven efficacious in clinical settings and their continued development is the current focus of many drug discovery groups.

Proteomics-bases Strategies in Kinase Drug Discovery

PKC Isotype Functions in T-Lymphocytes
Molecular and Systems-Biology Approaches to Define Signaling Pathways in Lymphocytes
Solving the IRAK-4 Enigma. Application of Kinase-Dead Knock-In Mice
Sensing, Presenting and Regulating PAMPS
Migration, Cell-Cell Interaction and Adhesion in the Immune System
The Role of Diacylglycerol Kinases in T Cell Anergy
Molecular Mechanisms that Control Leukocyte Extravasation Through Endothelial Cell Contacts
Fragment-Based Drug Discovery Using Rational Design.

ISBN	9783540735007
Article number	9783540735007
Media type	Book
Copyright year	2008
Publisher	Springer, Berlin
Length	187 pages
Illustrations	XIV, 187 p.
Language	English