This book offers a timely snapshot of computational methods applied to the study of bone tissue. The bone, a living tissue undergoing constant changes, responds to chemical and mechanical stimuli in order to maximize its mechanical performance. Merging perspectives from the biomedical and the engineering science fields, the book offers some insights into the overall behavior of this complex biological tissue. It covers three main areas: biological characterization of bone tissue, bone remodeling algorithms, and numerical simulation of bone tissue and adjacent structures. Written by clinicians and researchers, and including both review chapters and original research, the book offers an overview of the state-of-the-art in computational mechanics of bone tissue, as well as a good balance of biological and engineering methods for bone tissue analysis. An up-to-date resource for mechanical and biomedical engineers seeking new ideas, it also promotes interdisciplinary collaborations to advance research in the field.

Part I: Biological Characterization of Bone Tissue

Chapter 1. Bone: functions, structure and physiology
Chapter 2. Bone Quality Assessment at the Atomic Scale
Part II: Bone Remodelling algorithms
Chapter 3. Meshless, Bone Remodelling and Bone Regeneration Modelling
Chapter 4. Dynamic biochemical and cellular models of bone physiology: integrating remodeling processes, tumor growth and therapy
Chapter 5. Mathematical Modelling of Spatio-Temporal cell dynamics observed during Bone Remodelling
Chapter 6. A Mechanostatistical Approach to Multiscale Computational Bone Remodelling
Part III: Numerical simulation of bone tissue and adjacent structures
Chapter 7. Finite Element Analysis of Bone and Experimental Validation
Chapter 8. Computational modelling of tissue engineered cartilage constructs
Chapter 9. On the Computational Biomechanics of the Intervertebral Disc
Index.