The importance of the protein kinase family is underscored by numerous disease states that arise due to dysregulation of kinase activity. Recent progress in understanding the molecular regulation of kinases has led to the development of new therapeutics based on the inhibition of kinase activity. In this book, well known experts present their most recent findings on the fast developing kinase field. It will be of interest to basic researchers and the pharmaceutical industry.

Proteomics-bases Strategies in Kinase Drug Discovery

PKC Isotype Functions in T-Lymphocytes
Molecular and Systems-Biology Approaches to Define Signaling Pathways in Lymphocytes
Solving the IRAK-4 Enigma. Application of Kinase-Dead Knock-In Mice
Sensing, Presenting and Regulating PAMPS
Migration, Cell-Cell Interaction and Adhesion in the Immune System
The Role of Diacylglycerol Kinases in T Cell Anergy
Molecular Mechanisms that Control Leukocyte Extravasation Through Endothelial Cell Contacts
Fragment-Based Drug Discovery Using Rational Design.