Plant virus disease is a worldwide threat to agriculture. Environment-Friendly Antiviral Agents for Plants systematically describes the basic theory, new ideas, and new methods to discover novel antiviral agents through research on plant immune activation. The cutting-edge research methodology, technology and progress on novel antiviral agent innovation are systematically described. With abundant illustrations and figures, the book is intended for researchers and practitioners in the fields of pesticide science, plant protection, organic chemistry, fine chemicals, applied chemistry, environment chemistry and agriculture science.

Dr. Baoan Song and Dr. Song Yang are professors at the Center for R&D of Fine Chemicals, Guizhou University, China; Mr. Linhong Jin and Dr. Pinaki S. Bhadury are associate professors there.

1;Title Page ;2 2;Copyright Page ;3 3;Foreword;4 4;Preface;6 5;Table of Contents ;11 6;Introduction;17 7;Chapter 1 Studies on a-Aminophosphonates with Antiviral Activity;22 7.1;1.1 Organocatalytic Synthesis and Antiviral Activity of Asymmetric - a Aminophosphonates;22 7.1.1;1.1.1 Introduction;22 7.1.2;1.1.2 Materials and Methods;23 7.1.2.1;1.1.2.1 General;23 7.1.2.2;1.1.2.2 Synthesis and Characterization of Chiral Bronsted Catalyst 1.4 and Intermediates;24 7.1.2.3;1.1.2.3 General Procedure for Aldimines 1.2;25 7.1.2.4;1.1.2.4 General Procedure for Fluorinated Asymmetric a-aminophosphonates 1.5;26 7.1.2.5;1.1.2.5 Antiviral Biological Assay;26 7.1.3;1.1.3 Results and Discussion;27 7.1.4;1.1.4 Conclusions;33 7.2;1.2 Synthesis & Bioactivity of a-Aminophosphonates Containing Amide Moiety;34 7.2.1;1.2.1 Introduction;34 7.2.2;1.2.2 Materials and Methods;35 7.2.3;1.2.3 Results and Discussion;37 7.2.4;1.2.4 Conclusions;39 7.3;1.3 Green Synthesis & Bioactivity of a- Aminophosphonates Containing an Alkoxyethyl Moiety;40 7.3.1;1.3.1 Introduction;40 7.3.2;1.3.2 Materials and Methods;41 7.3.3;1.3.3 Results and Discussion;42 7.3.4;1.3.4 Conclusions;45 7.4;1.4 Green Synthesis & Bioactivity of Brominated a- Aminophosphonates;46 7.4.1;1.4.1 Introduction;46 7.4.2;1.4.2 Materials and Methods ;47 7.4.3;1.4.3 Results and Discussion;48 7.4.4;1.4.4 Conclusions;51 7.5;1.5 Synthesis & Bioactivity of a-Aminophosphonates Containing Trifluorinated Methyl Moiety;51 7.5.1;1.5.1 Introduction;51 7.5.2;1.5.2 Materials and Methods;52 7.5.2.1;1.5.2.1 Instruments;52 7.5.2.2;1.5.2.2 General procedure for the preparation of products 1.25a-1.25i;53 7.5.3;1.5.3 Results and Discussion;54 7.5.3.1;1.5.3.1 Chemistry;54 7.5.3.2;1.5.3.2 Biological Activity;58 7.5.4;1.5.4 Conclusions;59 7.6;1.6 Synthesis & Bioactivity of Chiral a-Aminophosphonates Containing Fluorine Moiety;59 7.6.1;1.6.1 Introduction;59 7.6.2;1.6.2 Materials and Methods;60 7.6.3;1.6.3 Results and Discussion;62 7.6.4;1.6.4 Conclusions;68 7.7;1.7 Green Synthesis of a-Aminophosphonates Containing Bromine and Fluorine under Ultrasonic Irradiation;69 7.7.1;1.7.1 Introduction;69 7.7.2;1.7.2 Materials and Methods;70 7.7.2.1;1.7.2.1 Apparatus and analysis;70 7.7.3;1.7.3 Results and Discussion;70 7.7.4;1.7.4 Conclusions;72 7.8;1.8 Synthesis & Bioactivity of a-Aminophosphonates Containing Isoxazole Moiety;73 7.8.1;1.8.1 Introduction;73 7.8.2;1.8.2 Materials and Methods;74 7.8.3;1.8.3 Results and Discussion;75 7.8.3.1;1.8.3.1 Crystal structure of 1.33c;77 7.8.4;1.8.4 Conclusions;79 7.9;1.9 Synthesis & Bioactivity of a-Aminophosphonates Containing Benzothiazole Moiety;81 7.9.1;1.9.1 Introduction;79 7.9.2;1.9.2 Materials and Methods;80 7.9.3;1.9.3 Results and Discussion;81 7.9.4;1.9.4 Conclusions;86 7.10; 1.10 Chiral Separation & Bioactivity of a-Aminophosphonates Containing Benzothiazole Moiety ;86 7.10.1;1.10.1 Introduction;86 7.10.2;1.10.2 Materials and Methods;87 7.10.2.1;1.10.2.1 Chemicals;87 7.10.2.2;1.10.2.2 Equipments;87 7.10.2.3;1.10.2.3 Instrumentation and Chromatographic conditions;88 7.10.2.4;1.10.2.4 Antiviral Bioassay;88 7.10.3;1.10.3 Results and Discussion;89 7.10.3.1;1.10.3.1 Analytical HPLC;89 7.10.3.2;1.10.3.2 Semi-preparative HPLC;95 7.10.3.3;1.10.3.3 Antiviral activity;97 7.10.4;1.10.4 Conclusions;99 7.11;1.11 Crystal Structure of O,O-Dipropyl-a-aminophosphonate Containing Benzothiazole Moiety;99 7.11.1;1.11.1 Introduction;99 7.11.2;1.11.2 Materials and Methods;99 7.11.3;1.11.3 Results and Discussion;100 7.12;References;101 8;Chapter 2 Synthesis, Characterization and Antiviral Activity of Cyanoacrylates and Derivatives;109 8.1;2.1 Synthesis and Antivival Activity of Cyanoacrylates Containing Phosphonyl Moiety;109 8.1.1;2.1.1 Introduction;109 8.1.2;2.1.2 Materials and Methods;110 8.1.3;2.1.3 Results and Discussion;111 8.1.4;2.1.4 Conclusions;116 8.2;2.2 Synthesis and Bioactivity of Cyanoacrylate Derivatives Containing Pyridine Moiety;116 8.2.1;2.2.1 Introduction;116 8.2.2;2.2.2 Materials and Methods;