Cancer
Cancer
This volume reviews advances in cancer chemotherapy research over the last 10 years and will be of interest to scientists engaged in drug research in the pharmaceutical industry, biotechnology and startup companies, academia and government institutions. Chapters written by leading experts in their field reflect a range of current medicinal chemistry approaches to small molecule drugs, including anti-hormonal therapy, growth factor inhibition, survival signaling, cell cycle inhibition, anti-angiogenics and anti-invasives. Each chapter covers the drug target and biological rationale, chemotypes, clinical status and future prospects in this rapidly developing area of drug research.
Overview
Anti-hormone Therapy: Principles of Endocrine Therapy of CancerInhibition of Growth Factor Signaling by Small-Molecule Inhibitors of ErbB, Raf, and MEK
Farnesyl Protein Transferase Inhibitors: Medicinal Chemistry, Molecular Mechanisms, and Progress in the Clinic
Survival Signaling
Progress in the Development of Agents to Control the Cell Cycle
HDAC Inhibition in Cancer Therapy: An Increasingly Intriguing Tale of Chemistry, Biology and Clinical Benefit
Development of Angiogenesis Inhibitors to Vascular Endothelial Growth Factor Receptor 2 for Cancer Therapy
Novel Small-Molecule Inhibitors of Src Kinase for Cancer Therapy
Bcr-Abl Kinase Inhibitors.
Bradbury, Rob
| ISBN | 978-3-642-06966-6 |
|---|---|
| Medientyp | Buch |
| Copyrightjahr | 2010 |
| Verlag | Springer, Berlin |
| Umfang | XIV, 452 Seiten |
| Abbildungen | XIV, 452 p. 32 illus., 4 illus. in color. |
| Sprache | Englisch |
