This volume describes our current understanding of the biological role of the delta-opioid receptor (DOR) system, focusing on its unique mechanisms of receptor trafficking and signaling in disease states. Part 1 covers the endogenous ligands that regulate the DOR system as well as novel compounds and therapies used to modulate the DOR system. Part 2 describes new insights into the localization and trafficking of the DOR and how ligand-directed signaling alters the fate of the receptor. Part 3 concentrates on the potential role of the DOR system in disease states, such as pain, mood, addiction, and Parkinson's disease. Throughout the book, the DOR system as a target for drug development will be discussed.

Part 1. DOPR Ligands

1. Delta Opioid Receptor (DOR) Ligands and Pharmacology: Development of Indolo- and Quinolinomorphinan Derivatives Based on the Message-Address Concept
2. Multifunctional Opioid Ligands
3. Contribution of Delta-Opioid Receptors to Pathophysiological Events Explored by Endogenous Enkephalins
Part 2. DOPR Signaling
4. Ligand-Directed Signaling at the Delta Opioid Receptor
5. Delta Opioid Receptor Expression and Function in Primary Afferent Somatosensory Neurons
6. Evidence and Function Relevance of Native DOR-MOR Heteromers
Part 3. DOPR and Disease
8. The Delta Opioid Receptor in Pain Control
9. Delta Opioid Receptors and Modulation of Mood and Emotion
10. Delta Opioid Pharmacology in Relation to Alcohol Behaviors
11. Delta Opioid Receptors: Learning and Motivation
12. Delta Opioid Pharmacology in Parkinson's Disease
13. Delta Opioid Receptor and Peptide: A Dynamic Therapy for Stroke and Other Neurological Disorders.-14. Delta Opioid Receptors and Cardioprotection
15. The Roles of Opioid Receptors in Cutaneous Wound Healing.