This book provides a comprehensive account of the pathogenesis and treatment of intestinal fibrosis, covering both the clinical and molecular aspects of the disease. It begins by describing the epidemiology and genetics of fibrostenosing IBD in Crohn's disease and Ulcerative colitis as well as the epigenetics and cellular and molecular mechanisms of the disease. Readers will obtain an in-depth overview of the disease from biomarkers and histology to surgical intervention, imaging and current and future drug therapies. Medical management of fibrosis, endoscopy and imaging as well as surgical approaches are all discussed. Through the links to videos contained in the book, the reader will become familiar with interventional procedures such as endoscopic balloon dilation and surgical techniques for stricturing IBD, such as resection and strictureplasties. This is an indispensable volume for anyone working on fibrostenotic IBD, such as gastroenterologists, internists, radiologists, colorectal surgeons, pathologists and researchers. It has been written by a team of top experts from North America, Asia and Europe.

 

Fibrostenotic Inflammatory Bowel Disease - a Cinderella story

Epidemiology and Natural History of Fibrostenosing Inflammatory Bowel Disease
Genetic influences on the development of fibrosis in inflammatory bowel disease
Epigenetic regulation of intestinal fibrosis
Cytokine and Anti-cytokine Agents as Future Therapeutics for Fibrostenosing IBD
Inflammation-independent mechanisms of intestinal fibrosis: the role of the extracellular matrix
Fat and Fibrosis
Environmental factors and their influence on intestinal fibrosis
Animal models and sources of mesenchymal cells in intestinal fibrosis
Fibrosis in Ulcerative Colitis
Histopathology of intestinal fibrosis
Clinical, Cellular and Serologic Biomarkers of intestinal fibrosis
The future of intestinal fibrosis imaging
Imaging in intestinal fibrosis. What is state of the art?
Medical therapy of stricturing IBD
Endoscopic therapy of intestinal strictures - What is state of the art?
Resectional surgery for intestinal strictures - What is state of the art?
Management of ileal pouch strictures and anal stricturing disease - A clinical challenge
The future of surgical therapy of stricturing IBD
Challenges of translation of anti-fibrotic therapies into clinical practice in IBD
What distinguishes mechanisms of fistula and stricture formation
The Pathogenesis of Intraabdominal Adhesions:Similarities and Differences to Luminal Fibrosis
Anti-fibrotic therapies from other organs - What the gut can learn from the liver, skin, lung and heart.