International experts are brought together in this book to give basic as well as clinical data on obesity and cachexia, and an integrated picture of the regulation of intermediary metabolism in both situations. The data provide evidence that tissue catabolism and anabolism are regulated by similar mechanisms, which again are the target of different hormonal and metabolic factors. This joint discussion of the similarities evident in both areas will greatly benefit future understanding and research in obesity and cachexia.

Central Role of the Liver in Metabolism

Regulation of Intermediary Metabolism by Substrate Supply, Hormone Concentrations and Nervous Activity
Hormonal Adaptations to Energy Intake and Determinants of Energy Expenditure
Hormonal Adaptation to Over- and Underfeeding
Hormonal and Metabolic Determinants of Energy Expenditure in Humans
Sympathetic Nervous System in the Regulation of Thermogenesis
Organ Contribution to Energy Expenditure in Humans
Thermogenic Role of Brown Adipose Tissue and Skeletal Muscle in Humans
Physiological Significance of Substrate Cycling in Humans
The Role of Triglyceride-Fatty Acid Cycling and Glucose Cycling in Thermogenesis and Amplification of Net Substrate Flux in Human Subjects
Hormones, Nutrition, Obesity, Cachexia
Hormonal and Nutritional Factors Contributory to Obesity
Thermogenesis in Obesity and Cachexia
Hormonal and Nutritional Factors Contributing to Tumour Cachexia
Catabolism in Patients with Liver Cirrhosis
Muscle Protein Turnover
Physiological and Pathophysiological Regulation of Human Muscle Protein Turnover
Nutritional Support Following Trauma and the Use of Indirect Calorimetry
Influence of Stress on the Endocrine System and Nutritional Support in Surgical Patients
Importance of Indirect Calorimetry for the Nutrition of Intensive Care Patients
Overview.