This book contains a series of contributions from internationally renowned academics with special expertise in one or other diseases which collectively are grouped under the heading myeloproliferative disorders. For the editors this term includes Ph-positive chronic myeloid leukemia but also the various Ph-negative variants, some of which provide fascinating insights into the molecular mechanisms of leukemia. There have been many recent developments in understanding the Pathophysiology and a number of therapeutic innovations in this area. One particular merit of this book is the speed with which it has been produced - an important factor in this very rapidly moving field.

Chronic Myeloid Leukemia - A Brief History

Bcr-Abl and Signal Transduction
Chronic Myeloid Leukemia: Biology of Advanced Phase
Clinical Features of CML
Signal Transduction Inhibitors in Chronic Myeloid Leukemia
Treatment with Tyrosine Kinase Inhibitors
Allogeneic Transplantation for CML
Autografting in Chronic Myeloid Leukemia
Monitoring Disease Response
New Therapies for Chronic Myeloid Leukemia
Immune Therapy of Chronic Myelogenous Leukemia
Therapeutic Strategies and Concepts of Cure in CML
BCR-ABL-Negative Chronic Myeloid Leukemia
Hypereosinophilic Syndrome
Chronic Idiopathic Myelofibrosis
Polycythemia Vera - Clinical Aspects
Polycythemia Vera and Other Polycythemic Disorders - Biological Aspects
Essential Thrombocythemia.