This text presents a comprehensive and state-of the-art approach to stereotactic and functional neurosurgery. Overarching sections include achieving stereotactic precision, defining trajectories and targets, the biophysics of stereotactic therapies, diseases and targets, and the future of functional neurosurgery.  Each section is designed to be inclusive of all relevant topics, serving as an unbiased resource to new clinicians in this field or established clinicians that are aiming to better understand complementary methods. Importantly, each section and the associated chapters can be used by basic and translational scientists as well as engineers and industry to better understand and deliver innovation to the field. Chapters within each section methodically analyze traditional and recently emerging concepts and techniques; address underlying principles with examples drawn from specific diseases and applications; and cover patient selection, target selection, available stereotactic methods, nuanced surgical methods, and clinical evidence across treatment options.
Written by experts in each area, Stereotactic and Functional Neurosurgery is a definitive guide to the latest developments in stereotactic targeting, electrode implantation, surgical treatment of neurological and psychiatric disorders, the renaissance of stereotactic lesions, and the frontier of restorative neurosurgery for a variety of disorders that have no other therapeutic options.

Part I: Achieving Stereotactic Precision

Traditional and Mini-Frames
Stereotactic Robots
Intraoperative Magnetic Resonance Imaging and Computed Tomoraphy
Frameless Image Guidance in Stereotactic Radiosurgery
Part II: Defining Trajectories and Targets
Principles of Safe Sterotactic Trajectories
Structural Imaging and Target Visualization
Network-Based Imaging and Connections
Microelectrode Recording in Neurosurgical Patients
Local Field Potentials and ECoG
Awake Testing to Confirm Target Engagement
Cloud-Based Stereotactic and Functional Neurosurgery and Registries
Part III: The Biophysics of Stereotactic Therapy
Responsive Neurostimulation
Spinal Stimulation
Peripheral Nerve Stimulation
Non-Invasive Central Neuromodulation with Transcranial Magnetic Stimulation
Ablation: Radiofrequency, Laser, and HIFU
Radiosurgery
Part IV: Diseases and Targets
Parkinson's Disease: Deep Brain Stimulation
Parkinson's Disease: Lesions
Deep Brain Stimulation and Essential Tremor
Essential Tremor: Lesions
Dystonia
Invasive Monitoring in Epilepsy Surgery
Epilepsy: Mesial Temporal
Neocortical Epilespy
Stereotactic Neurosurgery for the Management and Treatment of Pediatric Epilepsy
Epilepsy: Neuromodulation
Deep Brain Stimulation for Treatment-Resistant Depression
Deep Brain Stimulation for Obsessive Compulsive Disorder
Stereotactic Lesion Procedures for Obsessive-Compulsive Disorder
Deep Brain Stimulation for Gilles de la Tourette Syndrome
Neuromodulation for Chronic Pain
Chronic Pain: Lesion
Deep Brain Stimulation for Cluster Headache
Part V: The Future of Functional Neurosurgery
Developing New Indications: Strategies and Hurdles to Discovery
Imaging: Patient Selection, Targeting, and Outcome Biomarkers
The Design of Clinical Studies for Neuromodulation
Registries and Big Data.