Drug Discovery Targeting Metalloenzymes

Strategies and Applications

Drug Discovery Targeting Metalloenzymes

Strategies and Applications

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Comprehensively reviews database establishment, computational tools, experimental strategies, and biochemistry/crystallographic studies of metalloenzymes and their drug discovery applications.

Metalloenzyme Informatics and Drug Design
Metal-Binding Pharmacophores in Metalloenzyme Drug Discovery
Modelling Metalloenzyme Catalytic Mechanisms by QM/MM Calculations
Experimental Strategies in Metalloenzyme Mechanism Study and Drug Discovery
Targeting Metalloenzymes by Metallo-Drugs
Targeting Metallo-ß-Lactamases to Combat Antibiotic Resistance
Targeting Disease-Linked Metalloenzymes Involved in RNA metabolism
Cyclic Nucleotide Phosphodiesterases: Important Therapeutic Targets
HDAC, A Rising Star in Cancer Therapy
Drug Discovery Targeting Viral Metalloenzymes
Drug Discovery Targeting Carbonic Anhydrases
Targeting Autotaxin for Therapeutic Intervention
Targeting ENPP1 for Therapeutic Intervention
Drug Discovery Targeting Oxygen-Sensing Hypoxia-Inducible Factor Prolyl Hydroxylases
Hijacking Histone Demethylase KDM5B for Novel Therapeutics
Advances and Future Directions in Small-Molecule LpxC Inhibitors Targeting Gram-Negative Bacteria
Substrate and Inhibitor Discovery of Human Glutaminyl Cyclases
Drug Discovery Targeting Tryptophan/Indoleamine 2,3-Dioxygenase
ISBN 9783527354245
Artikelnummer 9783527354245
Medientyp Buch
Auflage 1. Auflage
Copyrightjahr 2025
Verlag Wiley-VCH
Umfang 544 Seiten
Sprache Englisch