RNA as a Drug Target
The Next Frontier for Medicinal Chemistry
RNA as a Drug Target
The Next Frontier for Medicinal Chemistry
Provides the concepts and tools for developing drug-like small molecules that selectively target RNA rather than proteins, including the first successful examples from the development pipeline of big pharma.
1. Introduction<br>2. RNA Structure Probing, Dynamics, Folding<br>3. High Resolution Structures of RNA<br>4. Screening and Lead Generation Techniques for RNA Binders<br>5. Chemical Matter that Binds RNA<br>6. MicroRNAs as Targets for Small Molecule Binders<br>7. Pre-mRNA Splicing Modulation<br>8. Prospects for Riboswitches in Drug Development<br>9. Small Molecules That Degrade RNA<br>10. Approaches to the Identification of Molecules Altering Programmed Ribosomal Frameshifting in Viruses<br>11. RNA-Protein Interactions: A New Approach for Drugging RNA Biology<br>12. Drugging the Epitranscriptome<br>13. A Perspective on RNA: The Next Frontier for Small Molecule Therapeutics<br>
Schneekloth, John
Pettersson, Martin
Mannhold, Raimund
Buschmann, Helmut
Holenz, Jörg
| ISBN | 9783527351008 |
|---|---|
| Artikelnummer | 9783527351008 |
| Medientyp | Buch |
| Auflage | 1. Auflage |
| Copyrightjahr | 2024 |
| Verlag | Wiley-VCH |
| Umfang | 392 Seiten |
| Abbildungen | 1 Farbabb. |
| Sprache | Englisch |
