This book provides an introduction to the latest gene mapping techniques and their applications in biomedical research and evolutionary biology. It especially highlights the advances made in large-scale genomic sequencing. Results of studies that illustrate how the new approaches have improved our understanding of the genetic basis of complex phenotypes including multifactorial diseases (e.g., cardiovascular disease, type 2 diabetes, and obesity), anatomic characteristics (e.g., the craniofacial complex), and neurological and behavioral phenotypes (e.g., human brain structure and nonhuman primate behavior) are presented.

Topics covered include linkage and association methods, gene expression, copy number variation, next-generation sequencing, comparative genomics, population structure, and a discussion of the Human Genome Project. Further included are discussions of the use of statistical genetic and genetic epidemiologic techniques to decipher the genetic architectureof normal and disease-related complex phenotypes using data from both humans and non-human primates.

The Utility of Genomics for Studying Primate Biology

The Human Genome Project: Where Are We Now and Where Are We Going?
Linkage Mapping: Localizing the Genes that Shape Human Variation
Association Studies to Map Genes for Disease-Related Traits in Humans
Gene Expression Studies and Complex Diseases
Copy Number Variations and Chronic Diseases
Applications of Genomic Methods to Studies of Wild Primate Populations
Comparative Genomics: Tools for Study of Complex Diseases
Genetic Structure and Its Implications for Genetic Epidemiology: Aleutian Island Populations
Mapping Genes in Isolated Populations: Lessons from the Old Order Amish
Genetics of Cardiovascular Disease in Minority Populations
Mapping of Susceptibility Genes for Obesity, Type 2 Diabetes, and the Metabolic Syndrome in Human Populations
Genetic Influence on the Human Brain
Variation, Genetics, and Evolution of the Primate Craniofacial Complex
Genetic Influences on Behavior in Nonhuman Primates.-Genomic Studies of Human Populations: Re-sequencing Approaches to the Identification of Human Quantitative Loci.