Gupta, Satya Prakash

Ion Channels and Their Inhibitors

Gupta, Satya Prakash

Ion Channels and Their Inhibitors

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Beschreibung Autorinnen & Autoren

Being the crucial components of living cells, ion channels are important targets of therapeutic agents. Historically, it has been challenging to develop drugs on this target class. A major issue with targets based on ion channel drug development is the identification of effective small chemical leads for medicinal chemistry optimization to the clinical candidate status. Thus enough attention has been paid to the study of structure and functions of ion channels and their potential inhibitors. The present book compiles important chapters authored by eminent workers in the field to cover important recent advances in the studies of the structure and functions of ion channels and their inhibitors, such as sodium Ion, potassium Ion, chloride Ion, calcium Ion channel inhibitors. The book may be of great use to the students and scientists working in the area of molecular biology, biochemistry, physiology, and neurobiology, and medicinal chemistry.

Structural and Functional Discrimination of Membrane

Proteins
Pharmacology of Hyperpolarization-Activated Cyclic Nucleotide-Gated (HCN) Channels
Advanced Molecular Modeling Techniques Applied to Ion Channels Blockers
Advances in Design and Development of Sodium Channel Blockers
Potassium Channel Blockers as Anti-arrhythmic Agents
hERG Potassium Channels in Drug Discovery and Development
Prediction of hERG Channel Inhibition Using in silico Techniques
Advances in Structure-Activity Relationship Studies on Potassium Channel Modulators

Calcium Ion Channels and Their Blockers
Therapeutic Potential of N-type Voltage Gated Ca²⁺Channel
Chloride Ion Channels: Structure, Functions, and Blockers.