This book brings together what is currently known in terms of basic research in the field of long noncoding RNAs (lncRNAs) and builds on this to delve more deeply in the specific roles that lncRNAs are playing during inflammation. The book provides readers with basic knowledge on lncRNAs: from understanding the complexity of the transcriptome, conservation, structure and the tools used to investigate these aspects, to how we use this information to study lncRNAs in a specific biological context. The volume covers the emerging roles of lncRNAs in the initial stages of inflammation as well as their roles in specific inflammatory diseases including arthritis, lupus, diabetes and cardiovascular disease. The book also shows the emerging interest in using lncRNAs as a therapeutic target and how this could impact our ability to diagnose and treat inflammatory diseases in the future.

Section 1: Overview

Chapter 1: Introduction and overview
Section 2: Basics of long noncoding RNA Classifications and functions
Chapter 2: The Complexity of the Mammalian Transcriptome
Chapter 3: Towards molecular mechanism in long non-coding RNAs: linking structure and function
Section 3: Long noncoding RNA and inflammation
Chapter 4: Long noncoding RNAs in Rheumatology
Chapter 5: LncRNA and Cardiovascular Disease
Chapter 6: A role for lncRNAs in regulating inflammatory and autoimmune responses underlying type 1 diabetes
Section 4: Long noncoding RNAs as Therapeutic targets
Chapter 7: LncRNA Biomarkers of Inflammation and Cancer
Chapter 8: Functional Implications of Intergenic GWAS SNPs in Immune Related lncRNAs
Chapter 9: Long noncoding RNAs as Therapeutic Targets
Section 5: Challenges and Future Directions
Chapter 10: Challenges and future directions for LncRNAs and inflammation.