This book addresses the therapeutic strategies to target mitochondrial metabolism in diseases where the function of that organelle is compromised, and it discusses the effective strategies used to create mitochondrial-targeted agents that can become commercially available drug delivery platforms. The consistent growth of research focused in understanding the multifaceted role of mitochondria in cellular metabolism, controlling pathways related with cell death, and ionic/redox regulation has extended the research of mitochondrial chemical-biological interactions to include various pharmacological and toxicological applications. Not only does the book extensively cover basic mitochondrial physiology, but it also links the molecular interactions within these pathways to a variety of diseases. It is one of the first books to combine state-of-the-art reviews regarding basic mitochondrial biology, the role of mitochondrial alterations in different diseases, and the importance of that organelle as a target for pharmacological and non-pharmacological interventions to improve human health. The different chapters highlight the chemical-biological linkages of the mitochondria in context with drug development and clinical applications.

Target Mitochondria

SECTION I-Mitochondrial Biology
Introduction: Mitochondria: the cell furnace
MItochondria: Where are They Coming From?
Mitochondrial Dynamics: A journey from Mitochondrial Morphology to MItochondrial Function and Quality
Mitochondrial ROS, Oxidative Stress.and Aging- The Mitochondrial Permeability Transition Pore
Mitochondrial Regulation of Cell Death
MItochondria in Liver Diseases
Mitochondria in Liver Regeneration,Energy Metabolism, and Posthepatectomy Liver Dysfunction
MItochondrial Remodeling in Cancer
Mitochondria in Kidney Disease
CNS diseases and disruption of Mitochondria
Mitochondrial disruption in cardiovascular diseases
.Drug-inducing Mitochondrial Toxicity
MItochondrial DNA: Functions and Role in Acquired Diseases
SECTION II-MItochondrial Therapeutics: From the Bench to Industry and Patient
The Evolution of Mitochondrial Toxicity Assessment in Industry
Designing Mitochondrial-Active Molecules: The Road to MitoQ and Beyond
Recovering Mitochondrial Function in Patients' Fibroblasts
Targeting Mitochondria with Sweat: Improving Mitochondrial Function with Physical Activity
Modulation of Cell Fate by Tauroursodexycholic Acid: All Paths Lead to Mitochondria
Pharmacological Targeting of the Mitchondrial Permeability Transition Pore
Strategies to Preserve/Improve Mitochondrial Function in Organ Preservation Solutions
MItochondrial Targeted Redox Active Compounds and the Astrocytemotoneuron Axis: relevance for the Treatment of Amyotrophic Lateral Sclerosis
Targeting the Mitochondrial Genome Through a Nanocarrier and the Regulation of the Mitochondrial Gene Experssion
Mitochoncrial Dysfunction and Chronic Disease: Treatment with Membrane Lipid Replacement and other Natural Supplements
Development of Mitochondrial-Directed Plastoquinones
Targeted Mitochondrial Genome Editing
Targeting Therpeutic Nucleic Acids into Mitochondria: A Long Challenge
Cell Permeable Peptides Targeting Mitochondria
MItochondrial -Directed Cancer Therapy
SkQ1: The Road from the Bench to the Market
MItochondrial Follies: Comic.