The aim of this book is not only to introduce readers with a broad spectrum of biological actions of the NOP receptor, but also to feature a detailed look at the N/OFQ-NOP receptor system, medicinal chemistry, pharmacology, and clinical data of NOP-targeted ligands. This special volume book - for the first time focusing on the NOP receptor - is designed to serve as a useful reference, stimulate more research on the N/OFQ-NOP receptor system, and lead to more development of NOP-related ligands for several therapeutic applications.

PART I. The N/OFQ-NOP Receptor System.- 1. The History of N/OFQ and the NOP Receptor

2. NOP-Targeted Peptide Ligands
3. NOP-Targeted Nonpeptide Ligands
4. Pharmacological Assays for Investigating the NOP Receptor
5. Electrophysiological Actions of N/OFQ
6. NOP Receptor Signaling Cascades
7.Regulation of the Genes Encoding the ppN/OFQ and NOP Receptor
PART II. Biological Actions of NOP Ligands
8.NOP-Related Mechanisms in Pain and Analgesia
9. NOP-Related Mechanisms in Substance Use Disorders
10. NOP Receptor Ligands and Parkinson's Disease
11. NOP Ligands for the Treatment of Anxiety and Mood Disorders
12. The Nociceptin/Orphanin FQ System and the Regulation of Memory
13. N/OFQ-NOP System in Food Intake
14. N/OFQ-NOP System in Peripheral and Central Immunomodulation
15. N/OFQ-NOP System and Airways
16. Effects of NOP-Related Ligands in Nonhuman Primates
PART III. First Clinical Studies with NOP Ligands.- 17. Nociceptin/Orphanin FQ and Urinary Bladder
18. Cebranopadol: A Novel First-in-Class Potent Analgesic Acting via NOP and Opioid Receptors
19. Therapeutic Approaches for NOP Receptor Antagonists in Neurobehavioral Disorders: Clinical Studies in Major Depressive Disorder and Alcohol Use Disorder with BTRX-246040 (LY2940094)
20. Correction to: Electrophysiological Actions of N/OFQ.