History and epidemiology

Pathophysiology: Molecular biology of plasma cell disorders.Alterations in microenvironment
Clinical Features: Imaging. Integrated innovative approach for diagnosis and staging
Therapy: High-dose chemotherapy and ABSCT
Allogeneic transplantation. Novel Drugs
Immunotherapeutic approaches
First-line treatment and maintenance
Relapse
Radiotherapy
Kyphoplasty
Supportive Therapy
Appendix: Staging and prognosis systems.