This book provides critical reviews of the role of neurotrophins and their receptors in a wide variety of diseases including neurodegenerative diseases like Huntington's syndrome, cognitive function, psychiatric disorders such as clinical depression, Rett syndrome, motoneurone disease, spinal cord injury, pain, metabolic disease and cardiovascular disease. It also contains contributions from leaders in the field dealing with the basic biology, transcriptional and post-translational regulation of the neurotrophins and their receptors. The present book will review all recent areas of progress in the study of neurotrophins and their biological roles.

The Neurotrophin Family: NGF, BDNF, NT3 and NT4

Deciphering Proneurotrophin Actions
Spatio-Temporal Intracellular Dynamics of Neurotrophins and Their Receptors. Implications for Neurotrophin Signaling and Neuronal Function
Neurotrophins: Transcription and Translation
Neurotrophin Receptors: Trk Receptors
The Biological Functions and Signaling Mechanisms of the p75 Neurotrophin Receptor
Sortilins in Neurotrophic Factor Signaling
The Biology of Neurotrophins: Neurotrophins in the Regulation of Cellular Survival and Death
BDNF and Synaptic Plasticity, Cognitive Function and Dysfunction
Nerve Growth Factor and Nociception: From Experimental Embryology to New Analgesic Therapy
Neurotrophins and the Regulation of Energy Balance and Body Weight
The Biology of Neurotrophins: Cardiovascular Function
Neurotrophin signalling and transcription programs interactions in the development of somatosensory neurons
Neurotrophins in Pathological Conditions: Huntington's Disease
Motoneuron Disease
Neurotrophic Factors in Spinal Cord Injury
Neurotrophins and Psychiatric Disorders
Brain Derived Neurotrophic Factor and Rett Syndrome
Modulation of Neurotrophin Signaling by Monoclonal Antibodies.