The book provides an overview on the different aspects of gene regulation from an mRNA centric viewpoint, including how mRNA is assembled and self-assembles in a complex consisting of RNA and proteins, and how its ability to be translated at the right time and space depends on many processes acting on the mRNAs, leading to a properly folded complex. This book shows how new technologies have led to a better understanding of these processes and their connected diseases.The book is written for scientists in fundamental and applied biomedical research working on different aspects of gene regulation. It is also targeted to an audience that is not implicated in these fields directly, but wants to gain a better understanding of mRNA biology.

Regulation of co-transcriptional mRNP assembly

mRNA export through the NPC
Roles of mRNA modifications in gene regulation
Studying mRNPs using single molecule approaches
Difference between mRNPs and lncRNAs?
RNPs and/or sequence motives in mRNA localization
mRNP structure
New RNA binding proteins: mRNP composition
Aggregation of repeats RNAs in neurodegenerative diseases
mRNA structural organization and translation
How to decide to make an mRNA  - degradation
Methods to study mRNP composition
mRNA-DNA kisses - R-loops
Forms of mRNA editing and their role in disease.