This research monograph provides new knowledge in the field of transmission electron microscopy and intramembrane morphology by means of the freeze etching technique, in the three dimensional arrangement of brain blood barrier by conventional and high resolution scanning electron microscopy, in confocal microscopy and GluR1 and N- Cadherin and CAMKII immunochytochemistry. The chapters present  new pathological, pathophysiology and chemical aspects concerning how the blood brain barrier structure and substructure participate in the mechanisms of brain edema formation and resolution. All current major concepts linking submicroscopic structures and nerve cell metabolism are included. 

This book emphasizes the importance of electron microscopic research in neurosurgery to understand the basic pathogenetic mechanisms of human brain edema. The material covers information valuable to all persons interested in the subject clinically or experimentally, from experimental neuroscientists and graduate students to neuropathologists, neurologists and neurosurgeons

Chapter I. Introductory overview to the study of blood brain barrier

Chapter II. Material and methods applied to the study of blood-brain barrier.

Chapter III. The three layered structure cerebellar capillaries as a model of blood brain barrier.

Chapter IV. Increased vesicular and vacuolar transendothelial transport in traumatic human brain edema.

Chapter V. Formation of transendothelial channels in traumatic human brain edema.

Chapter VI. The damage of endothelial junctions in perifocal human brain edema.

Chapter VII. Submicroscopic changes of cortical capillary pericytes in human traumatic brain edema

Chapter VIII. Ultrastructural alterations of human cortical capillary basement, and the glio-basement membrane dissociation process in perifocal brain edema

Chapter IX. The perivascular astroglial layer in traumatic human brain edema

Chapter X. Blood brain barrier disruption in traumatic brain injuries on aging brain