This book focuses on the contribution of cell dedifferentiation to the regenerative process in all body systems, as well as its underlying molecular mechanisms and applications.

The book is divided into four parts, the first of which addresses the history of cell dedifferentiation and regenerative medicine. In turn, Part II compares three routes by which cells change their phenotype: dedifferentiation, transdifferentiation, and reprogramming. Part III includes an extensive review of cell dedifferentiation events in all nine body systems for lower organisms and mammalians, respectively. The final part reviews the relationship between cell dedifferentiation and the development of cancer and several other diseases, while also outlining the prospects of and future research directions in cell dedifferentiation and regenerative medicine.

The main purpose of the book is to underline the importance of cell dedifferentiation in stem cell and regenerative medicine by providing a systematical review of dedifferentiation in all body systems, together with the latest reliable evidence.

A brief history of Regeneration

The origin of cells in Regeneration
Cell dedifferentiation
Cell transdifferentiation
Cell reprogramming
Dedifferentiation vs Transdifferentiation vs Reprogramming
The extent of cell dedifferentiation
Maintenance of cell differentiated identity
Unstable differentiated state
Epidermal cell dedifferentiation and skin regeneration
Peripheral nerve regeneration and Schwann cell dedifferentiation
Central nervous system and dedifferentiation
Dedifferentiation and Heart
Dedifferentiation and Kidney
Dedifferentiation and other 4 systems
The relationship between cell dedifferentiation and development of cancer and several diseases.