Although respiratory syncytial virus (RSV) has been a high priority for vaccine development for over 50 years now, still no vaccine is available and none has yet demonstrated sufficient promise to move to licensure. The success of RSV immune prophylaxis and the availability of ever more powerful tools to study the immune response and pathogenesis of disease, combined with the ability to construct a wide variety of vaccines using different vaccine platforms, give us grounds to believe that an RSV vaccine is within reach. This book brings together in one source what is currently known about the virus: its clinical and epidemiologic features; the host response and pathogenesis of the disease; vaccines, vaccine platforms, and treatment; and animal and tissue culture models of RSV infection. It is designed to organize the critical information relevant to RSV vaccine development, facilitate the assimilation of data, and speed progress toward producing a safe and effective vaccine.

Respiratory Syncytial Virus: Virology, Reverse Genetics, and Pathogenesis of Disease

Clinical and Epidemiologic Features of Respiratory Syncytial Virus
Influence of Respiratory Syncytial Virus Strain Differences on Pathogenesis and Immunity
Structure and Function of Respiratory Syncytial Virus Surface Glycoproteins
Respiratory Syncytial Virus and Reactive Airway Disease
Human Genetics and Respiratory Syncytial Virus Disease: Current Findings and Future Approaches
Innate Immune Responses to Respiratory Syncytial Virus Infection
The Adaptive Immune Response to Respiratory Syncytial Virus
Respiratory Syncytial Virus Mechanisms to Interfere with Type 1 Interferons
Host Gene Expression and Respiratory Syncytial Virus Infection
Consequences of Immature and Senescent Immune Responses for Infection with Respiratory Syncytial Virus
Respiratory Syncytial Virus Disease: Prevention and Treatment
Live-Attenuated Respiratory Syncytial Virus Vaccines
Subunit and Virus-Like Particle Vaccine Approaches for Respiratory Syncytial Virus
Gene-Based Vaccine Approaches for Respiratory Syncytial Virus
Bovine Model of Respiratory Syncytial Virus Infection
The Cotton Rat S. hispidus Model of Respiratory Syncytial Virus Infection
The Mouse Model of Respiratory Syncytial Virus Disease
Human Airway Epithelial Cell Cultures for Modeling Respiratory Syncytial Virus Infection
Challenges and Opportunities for Respiratory Syncytial Virus Vaccines.