Immunometabolism has emerged as an intersectional crossroad between metabolism and immune response. Over the past decade, it has become clear that most - if not all - immune cell functions are not separated from cellular metabolism. Although seminal works have addressed the metabolic fate of immune cells during differentiation and function, the physiological status of a given tissue is also dependent on the cell metabolism. The dialogue between immune cells and their microenvironment can also modulate cellular metabolism, which can trigger the onset and progression of a multitude of inflammation-mediated diseases. Thus, uncovering the specific characteristics of the metabolism in different immune cells types and in different conditions, can shed light into the molecular mechanisms of disease and help develop new drugs and therapeutic strategies to treat immune diseases.

Section 1. Introduction to ImmunometabolismCh.1.1. Overview of Immune responseCh.1.2. Metabolic PathwaysCh.1.3. Mitochondrial biogenesis and dynamics in healthy and diseasesCh.1.4. Epigenetic regulation of metabolic pathwaysCh.1.5. Metabolic pathways and cells signalingCh.1.6. Immunometabolism: from biochemistry to bench<br>Section 2. Metabolism of immune cellsCh.2.1. Metabolic profile of innate immune cellsCh.2.2. Metabolic profile of adaptive immune cellsCh.2.3. Metabolism and regulation of immune response Ch.2.4. Metabolic sensors and immunopathologyCh.2.5. Metabolic pathways and immune cells commitment and fateCh.2.6. Overlapping the immune response and cell metabolism reprograming<br>Section 3. Immunometabolism in health and in diseaseCh.3.1. Obesity, metabolic syndrome and inflammationCh.3.2. Metabolic reprogramming and cancerCh.3.3. Metabolic reprogramming and autoimmune diseasesCh.3.4. Metabolic reprogramming and infectious diseasesCh.3.5. Metabolic reprogramming and organ transplantationCh.3.6. Malnutrition, immune cell function and host physiologyCh.3.7. Immune regulation of browningCh.3.8. Microbiota, immune response and cell metabolism interfaceCh.3.9. Physical exercise and metabolic reprogramming Ch.3.10. Immunotherapies targeting metabolic pathwaysCh.3.11. Immunometabolism: translating basic science into clinics<br>