Adi Haber's thesis summarises the use of a new entity, the corrole, to combat one of the major cardiovascular diseases, atherosclerosis. She examines the effects of three rationally designed corrole-metal complexes on some of the many variables which contribute to the development of atherosclerosis. There is a focus on both the "bad" and "good" cholesterol carriers, LDL and HDL. Adi Haber proceeds from basic findings in pure chemistry through biochemical and cell culture tests to in vivo examinations. The work in this thesis shows that corroles are highly efficient both for early and late treatment of atherosclerosis in animals. These results will pave the way for ongoing regulated preclinical studies focussed on the development of metallocorroles as potential drugs for treating cardiovascular diseases.

Biologically relevant ROS/RNS

Atherosclerosis
The pro-atherogenic role of LDL and macrophages
The anti-atheroginicity of HDL
Common treatments for atherosclerosis
Corroles
Catalytic antioxidants
Electronic spectra
Research Goals
Results
Interactions of corroles with lipoproteins
Corrole-lipoproteins binding
Corrole distribution in serum
Spectral changes in the presence of lipoprotein components
The effect of corroles on oxidative-stress-induced lipoprotein damage
Cu+2-induced oxidation
Peroxynitrite-induced oxidation
Lipoprotein function
Interactions of corroles with macrophages
Fluorescence-based detection of 1-Ga
Chemiluminescence-based detection of 1-Fe
Cellular accumulation of 1-Fe versus iron(III) porphyrins
The effect of corroles on macrophage atherogenicity
Effect on oxidative-stress-induced cell death
Effect on macrophages cholesterol metabolism.-The effect of corroles on the development of atherosclerosis
Discussion
Interaction of corroles with lipoproteins
Corrole distribution in serum
Mode of 1-Fe binding to lipoproteins
Materials and Methods.