A reference is needed that addresses the recent progress in aspects of PK/PD methods and developments of nanoparticles for novel drug delivery systems. No other consolidated published reference discusses the PK/PD study of nanoparticle drug delivery systems. This book discusses the advantages of nanoparticle drug delivery systems (NPDDS) in enhancing the pharmacokinetics of many drugs that are not easily metabolized or that obtain the desired therapeutic effect with minimum toxicity.  The authors provide an overview of biodistribution with a focus on polymer and lipid nanoparticles.  
This thorough reference is divided into three parts: Modelling, Specific carries and their potential to treat specific diseases.

<b>Part 1-Modelling of PK/PD for NPDDS.-</b> Introduction to Nanoparticulate Drug Delivery Systems

Nanoparticle Properties Affecting Pharmacokinetics of NPDDS
Models Used for Biopharmaceutical Evaluation of NPDDS
Models Used in the Pharmacokinetic Evaluation of NPDDS
Models Used in the Pharmacodynamic Evaluation of NPDDS
Preclinical Animal Models For Experimental Design of Pharmacokinetic Studies of NPDDS
Pharmacokinetic Modelling Program (PKMP)
<b>Part 2-PK/PD for Specific Nanocarriers.-</b> Pharmacokinetic and Pharmacodynamics of Liposomal Nanoparticles
Pharmacokinetics of Polymer Matrix Drugs (NPDDS)
Pharmacokinetics of Long-Circulating NPDDS
Metallic Gold Nanoparticles in vivo Pharmacokinetics and X-ray Contrast imaging Studies
Muco-adhesive NPDDS In Vitro and Pharmacokinetics Studies
Pharmacokinetic and Tissue Distribution Study of Solid Lipid Nanoparticles
Factors Affecting the Clearance and Biodistribution of Polymeric Nanoparticles
PKPD of PLGA-PEG-PLGA  Triblock CoPolymeric Micelles
<b>Part 3-PKPD in Diseased Conditions for NPDDS.-</b> Bridging Bio-Nanoscience and Cancer Nanomedicine
Clearance Pathways and Tumor Targeting of Imaging Nanoparticles for Diagnostics
PLGA Nanoparticles for Oral Delivery-Nephrotoxicity and Pharmacokinetic Studies
Pharmacokinetics of Nanoparticle Systems for Pulmonary Delivery
In vivo Biodistribution and Pharmacokinetic Studies of NPDDS for Brain Targeting
Enhanced Bioavailability and Intestinal Uptake Nanoparticles After Oral Delivery
Nanoparticle Pharmacokinetic Profiling In Vivo Using Magnetic Resonance Imaging.<br>