A comprehensive and multidisciplinary guide to nanomaterials-based medicine

Nanomedicine is the study and application of nanomaterials-based medical techniques. In recent years it has very rapidly become indispensable in a huge range of medical contexts, from analysis of extreme life events to diagnosis and treatment of life-threatening intractable diseases, such as cancers and cardiovascular diseases. It has already transformed both research and clinical outcomes in many areas of medicine and promises to continue as the cutting-edge research and clinical area for the next generation of medical specialists.

Nanomedicine: Fundamentals, Synthesis, and Applications constitutes a comprehensive guide to this subfield and its recent advances. Beginning with a brief history of the field and introduction to its core principles, it thoroughly treats recent developments in this vital and ever-growing field. Its multidisciplinary approach equips the reader with a systematic overview of these life-saving developments in medicine.

Nanomedicine readers will also find:

• Edited by a leading researcher with decades of experience in both North America and China
• Detailed treatment of subjects including nanocarriers, nanomaterial bioprobes, multi-function nanodrugs, nanomedicine-mediated immunotherapy and/or physical ablation, and more
• A comprehensive volume treats every facet of the subject

Nanomedicine is a vital resource for biochemists, biomedical engineers, pharmaceutical chemists, physicists, and professionals in the biotechnological industries, as well as for clinicians looking to familiarize themselves with nanomedical techniques and instrumentation.

Preface xv

1 State of the Art in Nanomedicine 1
Yujun Song and Wei Hou

1.1 Intractable Diseases and Development of the Related Novel Therapy and Medicines 1

1.2 Key Features of Nanomedicines 4

1.3 Nanotechnology Translational Nanomedicine: Emergence and Progress 6

1.4 Interdisciplinary Features of Nanomedicines: Multi-mode and Multi-function Features Promoting Nanomedicine-mediated Immunotherapy and/or Physical Field Ablation Therapy for Subversive Therapy 12

1.5 Future Development of Nanomedicines by Coupling Advanced Biomedicines (Including Biochemistry and Biophysics), Modern Physicochemical Technologies, and Artificial Intelligence Technology 27

2 Fundamentals in Nanomedicine 49
Xiangrong Song, Mengran Guo, Zhongshan He, Xing Duan, and Wen Xiao

2.1 Design Theory of Nanomedicines 49

2.2 Progress in the Controlled Synthesis of Nanomaterials 55

2.3 Progress in the Surface Modification and Functionalization of Nanomaterials for Nanomedicines 60

3 Nanomedicine for Antitumors 73
Qiong Wu, Xinzhu Yang, Ruixue Zhu, and Yujun Song

3.1 Introduction 73

3.2 Liposomal Nanoparticles 75

3.3 Polymeric Nanoparticles 78

3.4 Inorganic Nanoparticles 82

3.5 Mixture (Hybrid) Nanoparticles 90

3.6 Cell Membrane Coating Nanotechnology 93

3.7 Challenges and Current Limitations 94

3.8 Conclusions 96

4 Nanomedicine for the Treatment of Nervous System Diseases 113
Xiaojian Cui and Yujun Song

4.1 Concepts and Types of Nanomedicines for Nervous System Diseases 113

4.2 Therapeutical Methods for Nervous System Diseases and Features of Current Nanomedicines 114

4.3 Synthesis Methods and Typical Examples (Including Clinical Trial) of Polymer-based Nanomedicines for Nervous System Diseases 116

4.4 Inorganic-based Nanomedicines: Synthesis Methods and Typical Application (Including Clinical) 117

4.5 Metallic-based Nanomedicines: Synthesis Methods and Typical Application (Including Clinical) 122

4.6 Multifunctional Nanomedicines for Nervous System Diseases 125

5 Nanomaterial Translational Nanomedicine for Anti-HIV and Anti-bacterial 131
Hao Luo and Yujun Song

5.1 Concepts, Anti-HIV Theory, and Types and Features of Current Nanomedicines 132

5.2 Polymer-based Nanomedicines: Synthesis Methods and Typical Application 142

5.3 Inorganic-based Nanomedicines: Synthesis Methods and Typical Application 146

5.4 Metallic-based Nanomedicines: Synthesis Methods and Typical Application 148

5.5 Multi-functional (Target) Nanomedicines 150

5.6 Future Development 152

6 Nanomedicine for Next-generation Dermal Management 157
Haibin Wu, Qian Chen, and Shen Hu

6.1 Introduction 157

6.2 Nano-biomaterials-based Therapeutics forWound Healing 159

6.3 Nano-biomaterials for Imaging and Monitoring of Cutaneous Wounds 176

6.4 Conclusion and Future Outlook 181

7 Nanomedicine for Targeting Delivery of Gene and Other DNA/RNA Therapies Based Viruses Engineering 197
Xiangrong Song, Mengran Guo, Zhongshan He, Xing Duan, and Wen Xiao

7.1 Targeting Delivery of Gene Therapies to the Tumors 198

7.2 Targeting Delivery of Gene-based Nanovaccines to the Spleen 199

7.3 Targeting Delivery of Gene-based Nanovaccines to the LNs 200

7.4 Targeting Delivery of Gene-based Nanomedicines to the Liver 200

7.5 Targeting Delivery of Gene-based Nanomedicines to the Lung 200

7.6 Targeting Delivery of Gene-based Nanomedicines to the Brain 202

8 Nanomedicine for Bio-imaging and Disease Diagnosis 207
Ziqi Wang and Yujun Song

8.1 Concepts, Types, and Features of Current Nanoprobes 207

8.2 Synthesis Methods 214

8.3 Typical Application