This book presents cutting-edge papers and perspectives on the transport of oxygen to tissues by scientists in a multitude of disciplines such as biochemistry, engineering, mathematics, medicine, physics, physiology, veterinary and complementary medicine. The book is composed of the following 6 parts: Brain Oxygenation and Function, Tumor Oxygenation and Metabolism, Muscle Oxygenation and Sports Medicine, Cell Metabolism and Tissue Oxygenation, Methodology of O₂ Measurements, and Special Topics. The articles in this book have been presented at the 42nd annual meeting of the International Society on Oxygen Transport to Tissue (ISOTT 2019) held in Albuquerque, New Mexico, USA, from July 28 to July 31, 2019. Academics, clinical and industry researchers, engineers, as well as graduate students who are interested in oxygen transport to tissue will find this book a great reference and a useful learning resource.

Part I. Oxygen Metabolism and Health Monitoring.- Chronic Ketosis Modulates HIF1 Mediated Inflammatory Response in Rat Brain.- Event Related NIRS and EEG Analysis for Mental Stress Monitoring.- Simulation Study of Breast Cancer Lipid Changes Affecting Membrane Oxygen Permeability.- Updated Evaluation of Cholesterol's Influence of Oxygen Permeability.- Systems biology model of cerebral oxygen delivery and metabolism during therapeutic hypothermia: application to the piglet model.- Effect of Adrenaline on Cerebral Blood Oxygenation Measured by NIRS in a Rat Asphyxia Cardiac Arrest Model.- Two consecutive invasive surgeries utilizing Zymogen Protein C (ZPC) that enhanced patient safety and reduced costs.- Scanning Tissue-Oxygen Needle-Probe.- Transcranial photobiomodulation of clearance of beta-amyloid from the mouse brain: the effects on meningeal lymphatic drainage and blood oxygen saturation of the brain.- Near-Infrared Spectroscopy Might Help Prevent Onset of Cerebral Hyperperfusion Syndrome

Part II. Oxygen Measurement and Modeling.- Online assessment of hemodynamics in suctioned volume of biological tissue by the embedded Near-infrared Spectroscopy sensor.- Skeletal Muscle Deoxygenation and its Relationship to Aerobic Capacity During Early and Late Stages of Aging.- Near-Infrared Spectroscopy (NIRS) of Muscle HbO2 and MBO2 Desaturation During Exercise.- Relationship between Corticosteroid Dose and Muscle Oxygen Consumption in Recipients of Hematopoietic Stem-Cell Transplantation.- Relationship between the Borg Scale Rating of Perceived Exertion and Leg Muscle Deoxygenation during Incremental Exercise in Healthy Adults.- Effects of Exercise Training on Cardiac and Skeletal Muscle Functions in Patients in Chronic Heart Failure.- Reduced Scattering Coefficient During Incremental Exercise is Constant without being Affected by Changes in Muscle Oxygenation or Hemodynamics.- Changes in the laterality of oxygenation in the prefrontal cortex and premotor area during a 20-min moderate-intensity cycling exercise.- Relationship Between Decrease of Oxygenation During Incremental Exercise, Partial Pressure End-Tidal Carbon Dioxide: Near-Infrared Spectroscopy Vector Analysis.- Cerebral Oxygenation Dynamics during Incremental Exercise: Comparison of Arm Cranking and Leg Cycling.- Localization of Deep of Deep Ischemia and Hemorrhage in Preterm Infants' Head with Near Infrared Optical Tomography: A Numerical Case Study.- Discerning Membrane Steady-State Oxygen Flux by Monte Carlo Markov Chain Modeling
Part III. Tumor Oxygenation and Modeling.- Role of MicroRNA Expression for Proliferation and Apoptosis of Tumor Cells: Impact of Hypoxia-Related Acidosis.- Functional Impact of Acidosis-regulated MicroRNAs on the Migration and Adhesion of Tumor Cells.- Impact of Acidosis-Regulated MicroRNAs on the Expression of Their Target Genes in Experimental Tumors In Vivo.- An Observation on Enhanced Extracellular Acidification and Lactate Production Induced by Inhibition of Lactate Dehydrogenase A.- Keynote Lecture - The Warburg Effect: Historical Dogma versus Current Rationale.- The Acidic Tumor Microenvironment Affects Epithelial-Mesenchymal Transition Markers as well as Adhesion of NCI-H358 Lung Cancer Cells.- Assessment of the probability of tumor control for prescribed doses based on imaging of oxygen partial pressure.- On the feasibility of Pulse Wave Velocity Imaging for remote assessment of physiological functions.- Mechanisms of sound-induced opening of the blood-brain barrier.- Multimodal measurements of brain tissue metabolism and perfusion in a neonatal model of hypoxic-ischaemic injury.- Cerebral Spreading Depression Transient Disruption of Cross Frequency Coupling in the Rat Brain: Preliminary Observations.- Long-Term Blue Light Exposure Changes Frontal and Oc