Science of Synthesis: Houben-Weyl Methods of Molecular Transformations is the entirely new edition of the acclaimed reference series Houben-Weyl, the standard synthetic chemistry resource since 1909. This new edition is published in English and will comprise 48 volumes published between the years 2000 and 2008.

Science of Synthesis is a quality reference work developed by a highly esteemed editorial board to provide a comprehensive and critical selection of reliable organic and organometallic synthetic methods. This unique resource is designed to be the first point of reference when searching for a synthesis strategy.

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1;Science of Synthesis - Volume 44: Cumulenes and Allenes;11.1;Title page;31.2;Imprint;51.3;Preface;61.4;Volume Editor's Preface;81.5;Overview;101.6;Table of Contents;121.7;44 Introduction;241.7.1;44.1 Product Class 1: Cumulenes;321.7.1.1;44.1.1 Product Subclass 1: [6]- and Higher Cumulenes;331.7.1.1.1;44.1.1.1 Synthesis of Product Subclass 1;331.7.1.1.1.1;44.1.1.1.1 Synthesis by Elimination;331.7.1.1.1.1.1;44.1.1.1.1.1 Method 1: Reduction of a,.-Dihydroxypolyynes;331.7.1.1.1.1.2;44.1.1.1.1.2 Method 2: Double Elimination of Methanol from 1,7-Dimethoxyhepta-2,4-diynes;341.7.1.2;44.1.2 Product Subclass 2: Hexapentaenes ([5]Cumulenes);351.7.1.2.1;44.1.2.1 Synthesis of Product Subclass 2;351.7.1.2.1.1;44.1.2.1.1 Synthesis by Elimination;351.7.1.2.1.1.1;44.1.2.1.1.1 Method 1: Dehydroxylation of Hexa-2,4-diyne-1,6-diols;351.7.1.2.1.1.2;44.1.2.1.1.2 Method 2: Debromination of 3,4-Dibromohexa-1,2,4,5-tetraenes;361.7.1.2.1.1.3;44.1.2.1.1.3 Method 3: Other Methods Involving Elimination;371.7.1.2.1.2;44.1.2.1.2 Synthesis Mediated by Carbene Species;381.7.1.2.1.2.1;44.1.2.1.2.1 Method 1: Dimerization of Allenylidene Species;381.7.1.2.1.2.1.1;44.1.2.1.2.1.1 Variation 1: Dimerization of Allenylidene Species Generated from Propargylic Precursors;381.7.1.2.1.2.1.2;44.1.2.1.2.1.2 Variation 2: Dimerization of Allenylidene Species Generated from Bromoallenes;401.7.1.2.1.2.1.3;44.1.2.1.2.1.3 Variation 3: Dimerization of Allenylidene--Chromium Species;401.7.1.2.1.2.2;44.1.2.1.2.2 Method 2: Trapping of Hexapentaenylidene Species;401.7.1.3;44.1.3 Product Subclass 3: Pentatetraenes ([4]Cumulenes);411.7.1.3.1;44.1.3.1 Synthesis of Product Subclass 3;411.7.1.3.1.1;44.1.3.1.1 Synthesis by Substitution;411.7.1.3.1.1.1;44.1.3.1.1.1 Method 1: Lithiation and Silylation of Hexa-2,4-diynes;411.7.1.3.1.1.2;44.1.3.1.1.2 Method 2: SN2. Substitution on Penta-2,4-diynyl Esters;421.7.1.3.1.2;44.1.3.1.2 Synthesis by Elimination;431.7.1.3.1.2.1;44.1.3.1.2.1 Method 1: Double Dehydrobromination of 2,4-Dibromopenta-1,4-dienes;431.7.1.3.1.2.2;44.1.3.1.2.2 Method 2: 1,2- and 1,4-Elimination from 5-Methoxypent-2-yn-1-ols;431.7.1.3.1.2.3;44.1.3.1.2.3 Method 3: Oxidation of Hexapentaenes Followed by Carbon Monoxide Elimination;441.7.1.3.1.2.4;44.1.3.1.2.4 Method 4: Reductive 1,4-Dechlorination of a 2,5-Dichloropent-1-en-3-yne;451.7.1.3.1.2.5;44.1.3.1.2.5 Method 5: 1,1-Dehalogenation and Rearrangement of 1,1-Dihalocyclopropanes;451.7.1.3.1.2.6;44.1.3.1.2.6 Method 6: Sulfur Elimination from Penta-1,2,3,4-tetraene Episulfides;461.7.1.3.1.2.7;44.1.3.1.2.7 Method 7: Wittig Reaction;471.7.1.3.1.2.7.1;44.1.3.1.2.7.1 Variation 1: Wittig Reaction of Carbon Suboxide with Alkylidenephosphoranes;471.7.1.3.1.2.7.2;44.1.3.1.2.7.2 Variation 2: Wittig Reaction of Alka-2,3-dienoyl Chlorides with Alkylidenephosphoranes;481.7.1.3.1.2.8;44.1.3.1.2.8 Method 8: Retro-Diels--Alder Reaction;481.7.1.4;44.1.4 Product Subclass 4: Butatrienes ([3]Cumulenes);491.7.1.4.1;44.1.4.1 Synthesis of Product Subclass 4;491.7.1.4.1.1;44.1.4.1.1 Synthesis by Substitution;491.7.1.4.1.1.1;44.1.4.1.1.1 Method 1: SN2. Substitution on Pent-4-en-2-ynyl Derivatives and Related Reactions;491.7.1.4.1.1.1.1;44.1.4.1.1.1.1 Variation 1: On Pent-4-en-2-ynyl Methanesulfinates with Alkylsilver(I) Reagents;491.7.1.4.1.1.1.2;44.1.4.1.1.1.2 Variation 2: On 2-(But-3-en-1-ynyl)oxiranes with Alkylsilver(I) Reagents;501.7.1.4.1.1.1.3;44.1.4.1.1.1.3 Variation 3: Reduction of Alka-4,5-dien-2-ynols or Related Alcohols by Lithium Aluminum Hydride;501.7.1.4.1.1.2;44.1.4.1.1.2 Method 2: SN2' Substitution on 2-Bromo-1-en-3-ynes;511.7.1.4.1.1.2.1;44.1.4.1.1.2.1 Variation 1: With Alkylcopper Reagents;511.7.1.4.1.1.2.2;44.1.4.1.1.2.2 Variation 2: With Soft Carbon Nucleophiles Catalyzed by a Palladium Complex;521.7.1.4.1.1.3;44.1.4.1.1.3 Method 3: Synthesis of Phosphinobutatrienes from 2-Vinyl-1H-phosphirenes and Alkyllithium Reagents;531.7.1.4.1.2;4