The Science of Synthesis Editorial Board, together with the volume editors and authors, is constantly reviewing the whole field of synthetic organic chemistry as presented in Science of Synthesis and evaluating significant developments in synthetic methodology. Four annual volumes updating content across all categories ensure that you always have access to state-of-the-art synthetic methodology.

1;Science of Synthesis: Knowledge Updates 2018/3;1 2;Title Page;7 3;Copyright;8 4;Preface;9 5;Abstracts;11 6;Overview;17 7;Table of Contents;19 8;10.2 Product Class 2: Benzo[c]furan and Its Derivatives;35 8.1;10.2.1 Product Subclass 1: Benzo[c]furans;35 8.1.1;10.2.1.1 Synthesis by Ring-Closure Reactions;46 8.1.1.1;10.2.1.1.1 Annulation to an Arene;46 8.1.1.1.1;10.2.1.1.1.1 Formation of One O-C and One C-C Bond;46 8.1.1.1.1.1;10.2.1.1.1.1.1 Method 1: From Aromatic Ketimines and Aldehydes by Rhenium Catalysis;46 8.1.1.1.1.1.1;10.2.1.1.1.1.1.1 Variation 1: From Ketimines and Benzyl Alcohol;48 8.1.1.1.2;10.2.1.1.1.2 Formation of One O-C Bond;49 8.1.1.1.2.1;10.2.1.1.1.2.1 Method 1: From 2-Alkynylbenzyl Alcohols or Their Derivatives;49 8.1.1.1.2.1.1;10.2.1.1.1.2.1.1 Variation 1: From 2-Alkynylbenzyl Alcohols Using a Palladium Catalyst;49 8.1.1.1.2.1.2;10.2.1.1.1.2.1.2 Variation 2: From 2-Alkynylbenzyl Alcohols or O-Silylated Derivatives and an Aryl Iodide Using a Palladium Catalyst;51 8.1.1.1.2.1.3;10.2.1.1.1.2.1.3 Variation 3: From 2-Ethynylbenzyl Alcohols via Carbocyclization with Aryl Iodides and Carbon Monoxide Using a Palladium Catalyst under Basic Conditions;53 8.1.1.1.2.2;10.2.1.1.1.2.2 Method 2: From (2-Alkynylaryl)aldehydes and Ketones and Fischer Carbene Complexes;55 8.1.1.1.2.2.1;10.2.1.1.1.2.2.1 Variation 1: From (2-Alkynylaryl)aldehydes or 2-Alkynylaryl Ketones and Fischer Carbene Complexes;55 8.1.1.1.2.2.2;10.2.1.1.1.2.2.2 Variation 2: From 2-Alkynylaldehydes and Chromium-Dicyanocarbene Complexes;58 8.1.1.1.2.2.3;10.2.1.1.1.2.2.3 Variation 3: From 2-Enynylbenzaldehydes and a Chromium-Carbene Complex;59 8.1.1.1.2.2.4;10.2.1.1.1.2.2.4 Variation 4: From 2-Ethynyl-N,N-dimethylbenzamide and a Fischer Carbene Complex;60 8.1.1.1.2.3;10.2.1.1.1.2.3 Method 3: From 2-Ethynylbenzoyl-Rhenium Complexes;61 8.1.1.1.2.4;10.2.1.1.1.2.4 Method 4: From 2-Alkynylbenzaldehydes by Palladium-Catalyzed Cycloreduction;63 8.1.1.1.2.5;10.2.1.1.1.2.5 Method 5: From Bis(2-aroylphenyl)acetylenes by Photochemical Exocyclic [2 + 2 + 2] Cycloaddition;64 8.1.1.1.2.6;10.2.1.1.1.2.6 Method 6: From 2-Alkenylbenzaldehydes;65 8.1.1.1.2.7;10.2.1.1.1.2.7 Method 7: From Acetals of 2-(Hydroxymethyl)benzaldehydes;66 8.1.1.1.2.8;10.2.1.1.1.2.8 Method 8: From 2-Acylbenzyl Alcohols;67 8.1.1.1.2.9;10.2.1.1.1.2.9 Method 9: From 1,2-Diacylbenzenes;69 8.1.1.1.2.9.1;10.2.1.1.1.2.9.1 Variation 1: Reduction with Borohydrides;69 8.1.1.1.2.9.2;10.2.1.1.1.2.9.2 Variation 2: Reduction with Dissolving Metals;70 8.1.1.1.2.9.3;10.2.1.1.1.2.9.3 Variation 3: From Phthalaldehyde and Trialkyl Phosphites Promoted by Lewis Acids;72 8.1.1.1.2.9.4;10.2.1.1.1.2.9.4 Variation 4: From Phthalaldehyde and Triethylsilane with a Scandium Catalyst;74 8.1.1.1.2.9.5;10.2.1.1.1.2.9.5 Variation 5: From 2-Aroylbenzaldehydes with Arylmagnesium Reagents;75 8.1.1.1.2.9.6;10.2.1.1.1.2.9.6 Variation 6: From 2-Benzoylbenzaldehyde with Arylboronic Acids Using Palladium or Rhodium Catalysts;76 8.1.1.1.2.9.7;10.2.1.1.1.2.9.7 Variation 7: From 2-Benzoylbenzaldehydes and Trimethylsilyl Cyanide;78 8.1.1.1.2.9.8;10.2.1.1.1.2.9.8 Variation 8: From 2-Acylbenzaldehydes and Potassium Cyanide;79 8.1.1.1.2.9.9;10.2.1.1.1.2.9.9 Variation 9: From 2-(Alkynylacyl)benzaldehydes;80 8.1.1.1.2.10;10.2.1.1.1.2.10 Method 10: From 2-Acylbenzyl Sulfoxides;81 8.1.1.1.2.10.1;10.2.1.1.1.2.10.1 Variation 1: From 2-Acylbenzyl Sulfoxides via Pummerer Reaction;81 8.1.1.1.2.10.2;10.2.1.1.1.2.10.2 Variation 2: From 2-Carbamoylbenzyl Sulfoxides via Pummerer Reaction;82 8.1.1.1.2.11;10.2.1.1.1.2.11 Method 11: From Methyl 2-Formylbenzoates;84 8.1.1.1.2.12;10.2.1.1.1.2.12 Method 12: From Derivatives of 2-(Diazomethyl)benzoic Acid;86 8.1.1.1.2.12.1;10.2.1.1.1.2.12.1 Variation 1: From Alkyl 2-(Diazomethyl)benzoates;86 8.1.1.1.2.12.2;10.2.1.1.1.2.12.2 Variation 2: From a 2-(Diazomethyl)benzamide;88 8.1.1.1.2.12.3;10.2.1.1.1.2.12.3 Variation 3: From 2-(Diazomethyl)benzamides and Intramolecular Diels-Alder Cycloaddition Reactions;88 8.1.1.1.2.13;1